Abstract
Chromosome analyses were carried out in eight patients with lymphoproliferative disorders of mature T and NK cells. Three cases were characterized by an abnormal expansion of granular lymphocytes (GL), one by a lymphoma of GL with leukemic spread, and four by an OKT4-T-CLL. In four patients cytogenic studies were performed on bone marrow cells; in seven patients peripheral blood lymphocytes were examined by either direct preparations or PHA-stimulated cultures. Six patients displayed a normal karyotype. Two cases belonging to the OKT4-T-CLL group had a chromosome number ranging from 44 to 47, with multiple numerical and structural clonal anomalies. Clonal anomalies could be a feature of patients with the more aggressive clinical course.
| Original language | English |
|---|---|
| Pages (from-to) | 171-176 |
| Number of pages | 6 |
| Journal | International Journal of Cancer |
| Volume | 34 |
| Issue number | 2 |
| Publication status | Published - 1984 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
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Chromosome studies in patients with T-CLL chronic lymphocyte leukemia and expansions of granular lymphocytes. / Dallapiccola, B.; Alimena, G.; Chessa, L.
In: International Journal of Cancer, Vol. 34, No. 2, 1984, p. 171-176.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chromosome studies in patients with T-CLL chronic lymphocyte leukemia and expansions of granular lymphocytes
AU - Dallapiccola, B.
AU - Alimena, G.
AU - Chessa, L.
PY - 1984
Y1 - 1984
N2 - Chromosome analyses were carried out in eight patients with lymphoproliferative disorders of mature T and NK cells. Three cases were characterized by an abnormal expansion of granular lymphocytes (GL), one by a lymphoma of GL with leukemic spread, and four by an OKT4-T-CLL. In four patients cytogenic studies were performed on bone marrow cells; in seven patients peripheral blood lymphocytes were examined by either direct preparations or PHA-stimulated cultures. Six patients displayed a normal karyotype. Two cases belonging to the OKT4-T-CLL group had a chromosome number ranging from 44 to 47, with multiple numerical and structural clonal anomalies. Clonal anomalies could be a feature of patients with the more aggressive clinical course.
AB - Chromosome analyses were carried out in eight patients with lymphoproliferative disorders of mature T and NK cells. Three cases were characterized by an abnormal expansion of granular lymphocytes (GL), one by a lymphoma of GL with leukemic spread, and four by an OKT4-T-CLL. In four patients cytogenic studies were performed on bone marrow cells; in seven patients peripheral blood lymphocytes were examined by either direct preparations or PHA-stimulated cultures. Six patients displayed a normal karyotype. Two cases belonging to the OKT4-T-CLL group had a chromosome number ranging from 44 to 47, with multiple numerical and structural clonal anomalies. Clonal anomalies could be a feature of patients with the more aggressive clinical course.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021134252&partnerID=8YFLogxK
M3 - Article
C2 - 6332081
AN - SCOPUS:0021134252
VL - 34
SP - 171
EP - 176
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 2
ER -