Chromosome studies in patients with T-CLL chronic lymphocyte leukemia and expansions of granular lymphocytes

B. Dallapiccola, G. Alimena, L. Chessa

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Chromosome analyses were carried out in eight patients with lymphoproliferative disorders of mature T and NK cells. Three cases were characterized by an abnormal expansion of granular lymphocytes (GL), one by a lymphoma of GL with leukemic spread, and four by an OKT4-T-CLL. In four patients cytogenic studies were performed on bone marrow cells; in seven patients peripheral blood lymphocytes were examined by either direct preparations or PHA-stimulated cultures. Six patients displayed a normal karyotype. Two cases belonging to the OKT4-T-CLL group had a chromosome number ranging from 44 to 47, with multiple numerical and structural clonal anomalies. Clonal anomalies could be a feature of patients with the more aggressive clinical course.

Original languageEnglish
Pages (from-to)171-176
Number of pages6
JournalInternational Journal of Cancer
Issue number2
Publication statusPublished - 1984


ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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