Abstract
Chromosome analyses were carried out in eight patients with lymphoproliferative disorders of mature T and NK cells. Three cases were characterized by an abnormal expansion of granular lymphocytes (GL), one by a lymphoma of GL with leukemic spread, and four by an OKT4-T-CLL. In four patients cytogenic studies were performed on bone marrow cells; in seven patients peripheral blood lymphocytes were examined by either direct preparations or PHA-stimulated cultures. Six patients displayed a normal karyotype. Two cases belonging to the OKT4-T-CLL group had a chromosome number ranging from 44 to 47, with multiple numerical and structural clonal anomalies. Clonal anomalies could be a feature of patients with the more aggressive clinical course.
Original language | English |
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Pages (from-to) | 171-176 |
Number of pages | 6 |
Journal | International Journal of Cancer |
Volume | 34 |
Issue number | 2 |
Publication status | Published - 1984 |
ASJC Scopus subject areas
- Cancer Research
- Oncology