Chronic administration of phosphatidylserine during ontogeny enhances subject-environment interactions and radial maze performance in C57BL/6 mice

Martine Ammassari-Teule, Sandro Fagioli, Marcella Maritati, Roberta Populin, Flaminia Pavone

Research output: Contribution to journalArticlepeer-review

Abstract

A longitudinal behavioral study was performed in mice exposed to the bovine brain phospholipid phosphatidylserine (BC-PS) from birth until sixty days. Examination of treated and control pups revealed no effect of the treatment on body weight nor on sensorimotor reflexes. At one and two months of age, when placed in an open field and, particularly, in the presence of a novel object, treated mice were found more interactive with their environment than control mice. Finally, when submitted to a radial eight-arm maze problem, choice accuracy was higher and maze-running strategies more adaptive in treated than in control adult mice. These results suggest a stimulating effect of the treatment on subject-environment interactions during ontogeny underlying improved cognitive abilities in adulthood.

Original languageEnglish
Pages (from-to)755-760
Number of pages6
JournalPhysiology and Behavior
Volume47
Issue number4
DOIs
Publication statusPublished - 1990

Keywords

  • Development
  • Open field-emotionality
  • Phosphatidylserine
  • Spatial memory

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience

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