Chronic alcohol use and first symptomatic epileptic seizures

M. Leone, C. Tonini, G. Bogliun, F. Monaco, R. Mutani, E. Bottacchi, P. Gambaro, E. Rocci, T. Tassinari, C. Cavestro, E. Beghi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: To establish whether chronic alcoholism and alcohol consumption are risk factors for developing a first symptomatic epileptic seizure. Methods: Multicentre case-control study of 293 patients (160 men, 133 women) with a first seizure symptomatic (either acute or remote) of head trauma, stroke, or brain tumour, matched to 444 hospital controls for centre, sex, age (±5 years), and underlying pathology. Results: The risk of first seizure in alcoholics was no higher than in non-alcoholics for men (odds ratio 1.2, 95% confidence interval 0.4 to 3.2) or women (1.5, 0.1 to 54.4). The odds ratio (both sexes) was 1.2 (0.8 to 1.7) for an average intake of absolute alcohol of 1-25 g/day, 0.9 (0.5 to 1.5) for 26-50 g/day, 1.6 (0.8 to 3.0) for 51-100 g/day, and 1.4 (0.5 to 3.5) for > 100 g/day. Conclusions: We found no evidence of an association between alcohol use or alcoholism and a first symptomatic seizure.

Original languageEnglish
Pages (from-to)495-499
Number of pages5
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume73
Issue number5
DOIs
Publication statusPublished - Nov 1 2002

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Alcoholism
Alcohol Withdrawal Seizures
Epilepsy
Seizures
Odds Ratio
Alcohols
Craniocerebral Trauma
Brain Neoplasms
Alcohol Drinking
Case-Control Studies
Ethanol
Stroke
Confidence Intervals
Pathology

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

Chronic alcohol use and first symptomatic epileptic seizures. / Leone, M.; Tonini, C.; Bogliun, G.; Monaco, F.; Mutani, R.; Bottacchi, E.; Gambaro, P.; Rocci, E.; Tassinari, T.; Cavestro, C.; Beghi, E.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 73, No. 5, 01.11.2002, p. 495-499.

Research output: Contribution to journalArticle

Leone, M, Tonini, C, Bogliun, G, Monaco, F, Mutani, R, Bottacchi, E, Gambaro, P, Rocci, E, Tassinari, T, Cavestro, C & Beghi, E 2002, 'Chronic alcohol use and first symptomatic epileptic seizures', Journal of Neurology, Neurosurgery and Psychiatry, vol. 73, no. 5, pp. 495-499. https://doi.org/10.1136/jnnp.73.5.495
Leone, M. ; Tonini, C. ; Bogliun, G. ; Monaco, F. ; Mutani, R. ; Bottacchi, E. ; Gambaro, P. ; Rocci, E. ; Tassinari, T. ; Cavestro, C. ; Beghi, E. / Chronic alcohol use and first symptomatic epileptic seizures. In: Journal of Neurology, Neurosurgery and Psychiatry. 2002 ; Vol. 73, No. 5. pp. 495-499.
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AU - Leone, M.

AU - Tonini, C.

AU - Bogliun, G.

AU - Monaco, F.

AU - Mutani, R.

AU - Bottacchi, E.

AU - Gambaro, P.

AU - Rocci, E.

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AU - Cavestro, C.

AU - Beghi, E.

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N2 - Objective: To establish whether chronic alcoholism and alcohol consumption are risk factors for developing a first symptomatic epileptic seizure. Methods: Multicentre case-control study of 293 patients (160 men, 133 women) with a first seizure symptomatic (either acute or remote) of head trauma, stroke, or brain tumour, matched to 444 hospital controls for centre, sex, age (±5 years), and underlying pathology. Results: The risk of first seizure in alcoholics was no higher than in non-alcoholics for men (odds ratio 1.2, 95% confidence interval 0.4 to 3.2) or women (1.5, 0.1 to 54.4). The odds ratio (both sexes) was 1.2 (0.8 to 1.7) for an average intake of absolute alcohol of 1-25 g/day, 0.9 (0.5 to 1.5) for 26-50 g/day, 1.6 (0.8 to 3.0) for 51-100 g/day, and 1.4 (0.5 to 3.5) for > 100 g/day. Conclusions: We found no evidence of an association between alcohol use or alcoholism and a first symptomatic seizure.

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