Chronic alcohol use and first symptomatic epileptic seizures

M. Leone, C. Tonini, G. Bogliun, F. Monaco, R. Mutani, E. Bottacchi, P. Gambaro, E. Rocci, T. Tassinari, C. Cavestro, E. Beghi

Research output: Contribution to journalArticlepeer-review


Objective: To establish whether chronic alcoholism and alcohol consumption are risk factors for developing a first symptomatic epileptic seizure. Methods: Multicentre case-control study of 293 patients (160 men, 133 women) with a first seizure symptomatic (either acute or remote) of head trauma, stroke, or brain tumour, matched to 444 hospital controls for centre, sex, age (±5 years), and underlying pathology. Results: The risk of first seizure in alcoholics was no higher than in non-alcoholics for men (odds ratio 1.2, 95% confidence interval 0.4 to 3.2) or women (1.5, 0.1 to 54.4). The odds ratio (both sexes) was 1.2 (0.8 to 1.7) for an average intake of absolute alcohol of 1-25 g/day, 0.9 (0.5 to 1.5) for 26-50 g/day, 1.6 (0.8 to 3.0) for 51-100 g/day, and 1.4 (0.5 to 3.5) for > 100 g/day. Conclusions: We found no evidence of an association between alcohol use or alcoholism and a first symptomatic seizure.

Original languageEnglish
Pages (from-to)495-499
Number of pages5
JournalJournal of Neurology, Neurosurgery and Psychiatry
Issue number5
Publication statusPublished - Nov 1 2002

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

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