Chronic aluminum administration to old rats results in increased levels of brain metal ions and enlarged hippocampal mossy fibers

Patrizia Fattoretti, Carlo Bertoni-Freddari, Marta Balietti, Belinda Giorgetti, Moreno Solazzi, Paolo Zatta

Research output: Contribution to journalArticle

Abstract

The effect of chronic aluminium administration (2 g/L/6 months) was investigated in the central nervous system (CNS) of old rats. The content of Al3+, Cu2+, Zn2+, and Mn2+ was measured in prosencephalon + mesencephalon, pons-medulla, and cerebellum. The area occupied by the mossy fibers in the hippocampal CA3 zone was also measured. In Al-treated rats the contents of Al3+, Cu2+, Zn 2+, and Mn2+ were significantly increased in prosencephalon + mesencephalon and pons-medulla, while no change was observed in the cerebellum except a Cu2+ decrease. The area occupied by the mossy fibers in the CA3 field was significantly increased (+32%) in Al-treated rats. Taken together, the present findings document that the aging CNS is particularly susceptible to aluminum toxic effects that may be responsible for a consistent rise in the cell load of oxidative stress. This may contribute, as an aggravating factor, to the development of neurodegenerative events, as observed in Alzheimer disease.

Original languageEnglish
Pages (from-to)44-47
Number of pages4
JournalAnnals of the New York Academy of Sciences
Volume1019
DOIs
Publication statusPublished - 2004

Keywords

  • Aluminum administration
  • Alzheimer disease
  • Brain metal ions
  • Hippocampus
  • Timm's reaction

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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