Chronic antioxidant supplementation impairs coronary endothelial function and myocardial perfusion in normal pigs

Daniele Versari, Elena Daghini, Martin Rodriguez-Porcel, Katherine Sattler, Offer Galili, Kevin Pilarczyk, Claudio Napoli, Lilach O. Lerman, Amir Lerman

Research output: Contribution to journalArticlepeer-review

Abstract

Experimental studies have shown the beneficial effects of antioxidant supplementation on endothelial function in the presence of increased endogenous oxidative stress, whereas limited data are available under normal conditions. The present study tested the hypothesis that in normal pigs long-term antioxidants would have deleterious effects on the cardiovascular system. Normal domestic pigs (V, n=6) were studied 12 weeks after dietary supplementation with vitamin E (100 IU/kg per day) and vitamin C (1 g/day) and compared with normal controls (C, n=7). Myocardial perfusion and permeability index were evaluated by electron beam computed tomography after intravenous adenosine and dobutamine. Coronary endothelial function was evaluated in vitro by organ chamber and coronary tissue studied by immunoblotting and staining. Myocardial perfusion response was lower in V than in C after adenosine (10.1±4.5 versus 53.4±5.2%; P

Original languageEnglish
Pages (from-to)475-481
Number of pages7
JournalHypertension
Volume47
Issue number3
DOIs
Publication statusPublished - Mar 2006

Keywords

  • Antioxidants
  • Endothelium
  • Myocardial
  • Nitric oxide synthase
  • Oxidative stress
  • Vasodilation

ASJC Scopus subject areas

  • Internal Medicine

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