Chronic Arterial Responses to Polymer-Controlled Paclitaxel-Eluting Stents

Comparison with Bare Metal Stents by Serial Intravascular Ultrasound Analyses: Data from the Randomized TAXUS-II Trial

Kengo Tanabe, Patrick W. Serruys, Muzaffer Degertekin, Giulio Guagliumi, Eberhard Grube, Charles Chan, Thomas Munzel, Jorge Belardi, Witold Ruzyllo, Luc Bilodeau, Henning Kelbaek, John Ormiston, Keith Dawkins, Louis Roy, Bradley H. Strauss, Clemens Disco, Jörg Koglin, Mary E. Russell, Antonio Colombo

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Background-Polymer-controlled paclitaxel-eluting stents have shown a pronounced reduction in neointimal hyperplasia compared with bare metal stents (BMS). The aim of this substudy was to evaluate local arterial responses through the use of serial quantitative intravascular ultrasound (IVUS) analyses in the TAXUS II trial. Methods and Results-TAXUS II was a randomized, double-blind study with 536 patients in 2 consecutive cohorts comparing slow-release (SR; 131 patients) and moderate-release (MR; 135 patients) paclitaxel-eluting stents with BMS (270 patients). This IVUS substudy included patients treated with one study stent who underwent serial IVUS examination after the procedure and at 6-month follow-up (BMS, 152 patients; SR, 81; MR, 81). The analyzed stented segment (15 mm) was divided into 5 subsegments in which mean vessel area (VA), stent area (SA), lumen area (LA), intrastent neointimal hyperplasia area (NIHA), and peristent area (VA-SA) were measured. NIHA was significantly reduced in SR (0.7±0.9 mm2, P2, P2), with no differences between the two paclitaxel-eluting release formulations. Longitudinal distribution of neointimal hyperplasia throughout the paclitaxel-eluting stent was uniform. Neointimal growth was independent of peristent area at postprocedure examination in all groups. There were progressive increases in peristent area from BMS to SR to MR (0.5± 1.7, 1.0±1.8, and 1.4±2.0 mm2, respectively; P

Original languageEnglish
Pages (from-to)196-200
Number of pages5
JournalCirculation
Volume109
Issue number2
DOIs
Publication statusPublished - Jan 20 2004

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Paclitaxel
Stents
Polymers
Metals
Hyperplasia
Double-Blind Method
Growth

Keywords

  • Angioplasty
  • Drugs
  • Restenosis
  • Stents

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Chronic Arterial Responses to Polymer-Controlled Paclitaxel-Eluting Stents : Comparison with Bare Metal Stents by Serial Intravascular Ultrasound Analyses: Data from the Randomized TAXUS-II Trial. / Tanabe, Kengo; Serruys, Patrick W.; Degertekin, Muzaffer; Guagliumi, Giulio; Grube, Eberhard; Chan, Charles; Munzel, Thomas; Belardi, Jorge; Ruzyllo, Witold; Bilodeau, Luc; Kelbaek, Henning; Ormiston, John; Dawkins, Keith; Roy, Louis; Strauss, Bradley H.; Disco, Clemens; Koglin, Jörg; Russell, Mary E.; Colombo, Antonio.

In: Circulation, Vol. 109, No. 2, 20.01.2004, p. 196-200.

Research output: Contribution to journalArticle

Tanabe, K, Serruys, PW, Degertekin, M, Guagliumi, G, Grube, E, Chan, C, Munzel, T, Belardi, J, Ruzyllo, W, Bilodeau, L, Kelbaek, H, Ormiston, J, Dawkins, K, Roy, L, Strauss, BH, Disco, C, Koglin, J, Russell, ME & Colombo, A 2004, 'Chronic Arterial Responses to Polymer-Controlled Paclitaxel-Eluting Stents: Comparison with Bare Metal Stents by Serial Intravascular Ultrasound Analyses: Data from the Randomized TAXUS-II Trial', Circulation, vol. 109, no. 2, pp. 196-200. https://doi.org/10.1161/01.CIR.0000109137.51122.49
Tanabe, Kengo ; Serruys, Patrick W. ; Degertekin, Muzaffer ; Guagliumi, Giulio ; Grube, Eberhard ; Chan, Charles ; Munzel, Thomas ; Belardi, Jorge ; Ruzyllo, Witold ; Bilodeau, Luc ; Kelbaek, Henning ; Ormiston, John ; Dawkins, Keith ; Roy, Louis ; Strauss, Bradley H. ; Disco, Clemens ; Koglin, Jörg ; Russell, Mary E. ; Colombo, Antonio. / Chronic Arterial Responses to Polymer-Controlled Paclitaxel-Eluting Stents : Comparison with Bare Metal Stents by Serial Intravascular Ultrasound Analyses: Data from the Randomized TAXUS-II Trial. In: Circulation. 2004 ; Vol. 109, No. 2. pp. 196-200.
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