Chronic B cell malignancies and bone marrow microenvironment

Paolo Ghia, Luisa Granziero, Marco Chilosi, Federico Caligaris-Cappio

Research output: Contribution to journalArticlepeer-review


Chronic B-lymphoid malignancies depend upon supportive interactions within specific microenvironments. Follicular lymphoma (FL), chronic lymphocytic leukaemia (CLL) and multiple myeloma (MM) cells accumulate in the bone marrow (BM) where they receive survival or growth signals from by-stander cells. However, they deeply differ in their interaction with the microenvironment. We propose a model where FL and CLL recreate in the BM the microenvironment most suitable to their growth by 'importing' the normal cells that usually nurse them in secondary lymphoid organs. In contrast, MM takes advantage of the actual BM microenvironment by 'instructing' it through an abnormal activation state.

Original languageEnglish
Pages (from-to)149-155
Number of pages7
JournalSeminars in Cancer Biology
Issue number2
Publication statusPublished - 2002


  • B lymphocytes
  • Bone marrow
  • Chronic lymphocytic leukaemia
  • Follicular lymphoma
  • Microenvironment
  • Multiple myeloma

ASJC Scopus subject areas

  • Cancer Research


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