Chronic baroreflex activation effects on sympathetic nerve traffic, baroreflex function, and cardiac haemodynamics in heart failure: A proof-of-concept study

Edoardo Gronda, Gino Seravalle, Gianmaria Brambilla, Giuseppe Costantino, Andrea Casini, Ali Alsheraei, Eric G. Lovett, Giuseppe Mancia, Guido Grassi

Research output: Contribution to journalArticle

Abstract

Aims Heart failure (HF) pathophysiology is believed to be mediated by autonomic dysfunction, including chronic sympathoexcitation and diminished baroreflex sensitivity, which correlate with mortality risk. Baroreflex activation therapy (BAT) is a device-based treatment providing chronic baroreflex activation through electrical stimulation of the carotid sinus. BAT chronically reduces sympathetic activity in resistant hypertension. The purpose of this investigation is to determine BAT effects in clinical HF.

and results In a single-centre, open-label evaluation, patients with NYHA class III HF, EF

Conclusion BAT was safe and provided chronic improvement in MSNA and clinical variables. Based on present understanding of HF pathophysiology, these results suggest that BAT may improve outcome in HF by modulating autonomic balance. Prospective, randomized trials to test the hypothesis are warranted.

Original languageEnglish
Pages (from-to)977-983
Number of pages7
JournalEuropean Journal of Heart Failure
Volume16
Issue number9
DOIs
Publication statusPublished - 2014

Keywords

  • Baroreflex
  • Heart failure
  • Non-pharmacological therapy
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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