Chronic cerebro-spinal venous insufficiency (CCSVI) and multiple sclerosis

A. Ghezzi, G. Comi, A. Federico

Research output: Contribution to journalArticlepeer-review

Abstract

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS caused by the interplay of genetic and environmental factors. In the last years, it has been suggested that an abnormal venous drainage due to stenosis or malformation of the internal jugular and/or azygous veins may play a major pathogenetic role in MS. This abnormality called chronic cerebro-spinal venous insufficiency (CCSVI) could result in increased permeability of blood brain barrier, local iron deposition and secondary multifocal inflammation. In the present paper, literature data in favour and against this hypothesis are reported. A great variability of CCSVI has been found in both MS patients (ranging from 0 to 100%) and in control subjects (from 0 to 23%). This large variability is explained by methodological aspects, problems in assessing CCSVI, and differences among clinical series. It is urgent to perform appropriate epidemiological studies to define the possible relationship between CCSVI and MS.

Original languageEnglish
Pages (from-to)17-21
Number of pages5
JournalNeurological Sciences
Volume32
Issue number1
DOIs
Publication statusPublished - Feb 2011

Keywords

  • CCSVI
  • Doppler sonography
  • Extracranial venous stenosis
  • MRI
  • Multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology

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