Chronic cerebrospinal venous insufficiency and iron deposition on susceptibility-weighted imaging in patients with multiple sclerosis: A pilot case-control study

R. Zivadinov, C. Schirda, M. G. Dwyer, M. E. Haacke, B. Weinstock-Guttman, E. Menegatti, M. Heininen-Brown, C. Magnano, A. M. Malagoni, D. S. Wack, D. Hojnacki, C. Kennedy, E. Carl, N. Bergsland, S. Hussein, G. Poloni, I. Bartolomei, F. Salvi, P. Zamboni

Research output: Contribution to journalArticlepeer-review

Abstract

Aim. Chronic cerebrospinal venous insufficiency (CCSVI) is a vascular phenomenon recently described in multiple sclerosis (MS) that is characterized by stenoses affecting the main extracranial venous outflow pathways and by a high rate of cerebral venous reflux that may lead to increased iron deposition in the brain. Aim of this study was to investigate the relationship between CCSVI and iron deposition in the brain of MS patients by correlating venous hemodynamic (VH) parameters and iron concentration in deep-gray matter structures and lesions, as measured by susceptibility-weighted imaging (SWI), and to preliminarily define the relationship between iron measures and clinical and other magnetic resonance imaging (MRI) outcomes. Methods. Sixteen (16) consecutive relapsing-remitting MS patients and 8 age- and sex-matched healthy controls (HC) were scanned on a GE 3T scanner, using SWI. Results. All 16 MS patients fulfilled the diagnosis of CCSVI (median VH=4), compared to none of the HC. In MS patients, the higher iron concentration in the pulvinar nucleus of the thalamus, thalamus, globus pallidus, and hippocampus was related to a higher number of VH criteria (P

Original languageEnglish
Pages (from-to)158-175
Number of pages18
JournalInternational Angiology
Volume29
Issue number2
Publication statusPublished - Apr 2010

Keywords

  • Diagnostic imaging
  • Iron deposition
  • Multiple sclerosis
  • Venous insufficiency

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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