TY - JOUR
T1 - Chronic cerebrospinal venous insufficiency and iron deposition on susceptibility-weighted imaging in patients with multiple sclerosis
T2 - A pilot case-control study
AU - Zivadinov, R.
AU - Schirda, C.
AU - Dwyer, M. G.
AU - Haacke, M. E.
AU - Weinstock-Guttman, B.
AU - Menegatti, E.
AU - Heininen-Brown, M.
AU - Magnano, C.
AU - Malagoni, A. M.
AU - Wack, D. S.
AU - Hojnacki, D.
AU - Kennedy, C.
AU - Carl, E.
AU - Bergsland, N.
AU - Hussein, S.
AU - Poloni, G.
AU - Bartolomei, I.
AU - Salvi, F.
AU - Zamboni, P.
PY - 2010/4
Y1 - 2010/4
N2 - Aim. Chronic cerebrospinal venous insufficiency (CCSVI) is a vascular phenomenon recently described in multiple sclerosis (MS) that is characterized by stenoses affecting the main extracranial venous outflow pathways and by a high rate of cerebral venous reflux that may lead to increased iron deposition in the brain. Aim of this study was to investigate the relationship between CCSVI and iron deposition in the brain of MS patients by correlating venous hemodynamic (VH) parameters and iron concentration in deep-gray matter structures and lesions, as measured by susceptibility-weighted imaging (SWI), and to preliminarily define the relationship between iron measures and clinical and other magnetic resonance imaging (MRI) outcomes. Methods. Sixteen (16) consecutive relapsing-remitting MS patients and 8 age- and sex-matched healthy controls (HC) were scanned on a GE 3T scanner, using SWI. Results. All 16 MS patients fulfilled the diagnosis of CCSVI (median VH=4), compared to none of the HC. In MS patients, the higher iron concentration in the pulvinar nucleus of the thalamus, thalamus, globus pallidus, and hippocampus was related to a higher number of VH criteria (P
AB - Aim. Chronic cerebrospinal venous insufficiency (CCSVI) is a vascular phenomenon recently described in multiple sclerosis (MS) that is characterized by stenoses affecting the main extracranial venous outflow pathways and by a high rate of cerebral venous reflux that may lead to increased iron deposition in the brain. Aim of this study was to investigate the relationship between CCSVI and iron deposition in the brain of MS patients by correlating venous hemodynamic (VH) parameters and iron concentration in deep-gray matter structures and lesions, as measured by susceptibility-weighted imaging (SWI), and to preliminarily define the relationship between iron measures and clinical and other magnetic resonance imaging (MRI) outcomes. Methods. Sixteen (16) consecutive relapsing-remitting MS patients and 8 age- and sex-matched healthy controls (HC) were scanned on a GE 3T scanner, using SWI. Results. All 16 MS patients fulfilled the diagnosis of CCSVI (median VH=4), compared to none of the HC. In MS patients, the higher iron concentration in the pulvinar nucleus of the thalamus, thalamus, globus pallidus, and hippocampus was related to a higher number of VH criteria (P
KW - Diagnostic imaging
KW - Iron deposition
KW - Multiple sclerosis
KW - Venous insufficiency
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M3 - Article
C2 - 20351672
AN - SCOPUS:77952847537
VL - 29
SP - 158
EP - 175
JO - International Angiology
JF - International Angiology
SN - 0392-9590
IS - 2
ER -