Chronic cerebrospinal venous insufficiency is not associated with chronic venous disorders: A case-control study

Maurizio A. Leone, Olga Raymkulova, Piergiorgio Lochner, Laura Bolamperti, Gianandrea Rivadossi, Alessandro Stecco, Giuseppe Zaccala, Maurizio Maggio, William Liboni, Marilena Guido, Lorenzo Coppo, Imperiale Daniele

Research output: Contribution to journalArticle

Abstract

Objectives: To evaluate the relationship between chronic cerebrospinal venous insufficiency (CCSVI) and the presence of a Chronic Venous Disorder (CVD). Method: We included 55 subjects with CCSVI aged >18 years, and 186 controls without CCSVI. Each subject was evaluated with color Doppler sonography in accordance with Zamboni’s five criteria, examined by two neurologists and interviewed with an ad-hoc designed form. The neurologists and the sonographers were mutually blinded. CVD were classified according to CEAP. Results: Mean age was 42 years (SD = 9) in cases and 43 years (10) in controls (p = ns). The odds ratios in subjects CCSVI were 0.6 (0.2-2.2) for CEAP 1, 0.9 (0.2-4.5) for CEAP 2, and 1.0 (0.6-1.9) for family history of varicose veins. The prevalence of CVD and, family history of varicose veins, was similar between cases and controls for each Zamboni criterion. Conclusions: We found no association of CCSVI with the presence of CVD or family history of varicose veins.

Original languageEnglish
Pages (from-to)736-738
Number of pages3
JournalPhlebology
Volume30
Issue number10
DOIs
Publication statusPublished - Jan 1 2015

Keywords

  • Blinding
  • CCSVI
  • CEAP
  • Multiple sclerosis
  • Veins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Leone, M. A., Raymkulova, O., Lochner, P., Bolamperti, L., Rivadossi, G., Stecco, A., Zaccala, G., Maggio, M., Liboni, W., Guido, M., Coppo, L., & Daniele, I. (2015). Chronic cerebrospinal venous insufficiency is not associated with chronic venous disorders: A case-control study. Phlebology, 30(10), 736-738. https://doi.org/10.1177/0268355514544782