Chronic cerebrospinal venous insufficiency is not associated with chronic venous disorders

A case-control study

Maurizio A. Leone, Olga Raymkulova, Piergiorgio Lochner, Laura Bolamperti, Gianandrea Rivadossi, Alessandro Stecco, Giuseppe Zaccala, Maurizio Maggio, William Liboni, Marilena Guido, Lorenzo Coppo, Imperiale Daniele

Research output: Contribution to journalArticle

Abstract

Objectives: To evaluate the relationship between chronic cerebrospinal venous insufficiency (CCSVI) and the presence of a Chronic Venous Disorder (CVD). Method: We included 55 subjects with CCSVI aged >18 years, and 186 controls without CCSVI. Each subject was evaluated with color Doppler sonography in accordance with Zamboni’s five criteria, examined by two neurologists and interviewed with an ad-hoc designed form. The neurologists and the sonographers were mutually blinded. CVD were classified according to CEAP. Results: Mean age was 42 years (SD = 9) in cases and 43 years (10) in controls (p = ns). The odds ratios in subjects CCSVI were 0.6 (0.2-2.2) for CEAP 1, 0.9 (0.2-4.5) for CEAP 2, and 1.0 (0.6-1.9) for family history of varicose veins. The prevalence of CVD and, family history of varicose veins, was similar between cases and controls for each Zamboni criterion. Conclusions: We found no association of CCSVI with the presence of CVD or family history of varicose veins.

Original languageEnglish
Pages (from-to)736-738
Number of pages3
JournalPhlebology
Volume30
Issue number10
DOIs
Publication statusPublished - Jan 1 2015

Fingerprint

Venous Insufficiency
Case-Control Studies
Varicose Veins
Doppler Color Ultrasonography
Odds Ratio

Keywords

  • Blinding
  • CCSVI
  • CEAP
  • Multiple sclerosis
  • Veins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Leone, M. A., Raymkulova, O., Lochner, P., Bolamperti, L., Rivadossi, G., Stecco, A., ... Daniele, I. (2015). Chronic cerebrospinal venous insufficiency is not associated with chronic venous disorders: A case-control study. Phlebology, 30(10), 736-738. https://doi.org/10.1177/0268355514544782

Chronic cerebrospinal venous insufficiency is not associated with chronic venous disorders : A case-control study. / Leone, Maurizio A.; Raymkulova, Olga; Lochner, Piergiorgio; Bolamperti, Laura; Rivadossi, Gianandrea; Stecco, Alessandro; Zaccala, Giuseppe; Maggio, Maurizio; Liboni, William; Guido, Marilena; Coppo, Lorenzo; Daniele, Imperiale.

In: Phlebology, Vol. 30, No. 10, 01.01.2015, p. 736-738.

Research output: Contribution to journalArticle

Leone, MA, Raymkulova, O, Lochner, P, Bolamperti, L, Rivadossi, G, Stecco, A, Zaccala, G, Maggio, M, Liboni, W, Guido, M, Coppo, L & Daniele, I 2015, 'Chronic cerebrospinal venous insufficiency is not associated with chronic venous disorders: A case-control study', Phlebology, vol. 30, no. 10, pp. 736-738. https://doi.org/10.1177/0268355514544782
Leone, Maurizio A. ; Raymkulova, Olga ; Lochner, Piergiorgio ; Bolamperti, Laura ; Rivadossi, Gianandrea ; Stecco, Alessandro ; Zaccala, Giuseppe ; Maggio, Maurizio ; Liboni, William ; Guido, Marilena ; Coppo, Lorenzo ; Daniele, Imperiale. / Chronic cerebrospinal venous insufficiency is not associated with chronic venous disorders : A case-control study. In: Phlebology. 2015 ; Vol. 30, No. 10. pp. 736-738.
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