Chronic cocaine alters limbic extracellular dopamine. Neurochemical basis for addiction

Assunta Imperato; Andrea Mele; Maria G. Scrocco; Stefano Puglisi-Allegra

doi:10.1016/0014-2999(92)90349-9

Chronic cocaine alters limbic extracellular dopamine. Neurochemical basis for addiction

Assunta Imperato, Andrea Mele, Maria G. Scrocco, Stefano Puglisi-Allegra

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

The extracellular concentration of dopamine in the ventral striatum was measured daily by means of brain microdialysis. Chronic cocaine (10 mg/kg twice daily) altered the dopamine output compared to that in vehicle-injected rats, inducing a pronounced increase in the first 3 days followed by a clear-cut decrease. This reduction in the output of dopamine during chronic cocaine as well as during withdrawal may be neurochemical substrate for the additive properties of concaine.

Original language	English
Pages (from-to)	299-300
Number of pages	2
Journal	European Journal of Pharmacology
Volume	212
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(92)90349-9
Publication status	Published - Mar 3 1992

Keywords

Addiction
Cocaine (chronic)
Dopamine

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Pharmacology

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