Chronic cocaine alters limbic extracellular dopamine. Neurochemical basis for addiction

Assunta Imperato, Andrea Mele, Maria G. Scrocco, Stefano Puglisi-Allegra

Research output: Contribution to journalArticlepeer-review

Abstract

The extracellular concentration of dopamine in the ventral striatum was measured daily by means of brain microdialysis. Chronic cocaine (10 mg/kg twice daily) altered the dopamine output compared to that in vehicle-injected rats, inducing a pronounced increase in the first 3 days followed by a clear-cut decrease. This reduction in the output of dopamine during chronic cocaine as well as during withdrawal may be neurochemical substrate for the additive properties of concaine.

Original languageEnglish
Pages (from-to)299-300
Number of pages2
JournalEuropean Journal of Pharmacology
Volume212
Issue number2-3
DOIs
Publication statusPublished - Mar 3 1992

Keywords

  • Addiction
  • Cocaine (chronic)
  • Dopamine

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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