Chronic daily headache: Risk factors and pathogenetic considerations

S. Cevoli, E. Sancisi, G. Pierangeli, D. Grimaldi, S. Zanigni, M. Nicodemo, P. Cortelli, P. Montagna

Research output: Contribution to journalArticlepeer-review


Chronic daily headache (CDH) is a major clinical concern, although it is still plagued by difficulties with classification and definitions. CDH usually evolves from an episodic headache, mainly migraine. Drug overuse and other somatic or psychological traits are considered risk factors for CDH. The neurobiology underlying this clinical evolution is incompletely understood. There is evidence of a progressive dysfunction of central pain systems in some individuals probably genetically predisposed.

Original languageEnglish
JournalNeurological Sciences
Issue numberSUPPL. 2
Publication statusPublished - Sep 2006


  • Chronic headache
  • Drug abuse
  • Migraine
  • Pathophysiology
  • Risk factors

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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