Chronic dihydroergotoxine treatment affects the number of dopamine recognition sites in rat striatum

F. Battaini, S. Govoni, R. A. Rius, P. F. Spano, M. Trabucchi

Research output: Contribution to journalArticle

Abstract

Ergot derivatives have been proposed to have ameliorative effects in various pathological conditions where dopaminergic transmission is believed to be impaired, namely Parkinson's desease, amenorrhea-galac torrhea syndrome, and in the treatment of behavioural disturbances of the elderly. To get more insight into a possible involvement of a direct action of ergot derivatives on dopamine receptors we studied the effect of acute and chronic dihydroergotoxine (DHT) treatment on 3H-Spiroperidol and 3H-N-Propylnorapomorphine (3H-NPA) binding to rat striatal membrane preparations. The results are in favor of an interaction of ergot derivatives with dopamine recognition sites both after acute and chronic treatment.

Original languageEnglish
Pages (from-to)605-611
Number of pages7
JournalPharmacological Research Communications
Volume16
Issue number6
DOIs
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Pharmacology

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