TY - JOUR
T1 - Chronic diseases, medical history and familial cancer, and risk of leukemia and non-Hodgkin’s lymphoma in an adult population
T2 - a case–control study
AU - Parodi, Stefano
AU - Santi, Irene
AU - Marani, Enza
AU - Casella, Claudia
AU - Puppo, Antonella
AU - Sola, Simona
AU - Fontana, Vincenzo
AU - Stagnaro, Emanuele
PY - 2015/7/13
Y1 - 2015/7/13
N2 - Purpose: This investigation was aimed at evaluating the association between chronic diseases, medical history and familial cancer, and the risk of developing hematological malignancies. Methods: Data were drawn from a population-based case–control study carried out to assess the risk of non-Hodgkin’s lymphoma and leukemia in an adult population exposed to environmental air pollution in Northern Italy. Each case was classified according to the WHO ICD-O-3 classification. Statistical analyses were performed by multivariable unconditional logistic regression in 573 interviewed subjects (199 lymphoid cases, 95 myeloid cases, and 279 healthy controls). Results: Lymphoid malignancies were associated with a history of gastroduodenal ulcer (OR 2.1, 95 % CI 1.2–3.6), rheumatoid arthritis (OR 4.4, 95 % CI 1.3–19.0), anemia (OR 3.3, 95 % CI 1.2–9.3), cholecystectomy (OR 2.9, 95 % CI 1.0–8.0), heavy diagnostic X-ray exposure (OR 2.1, 95 % CI 1.3–3.7), and a familial risk of non-Hodgkin’s lymphoma (OR 10.1, 95 % CI 1.3–458). Myeloid malignancies were associated with non-neoplastic thyroid diseases (OR 6.2, 95 % CI 1.7–35.6) and anemia (OR 6.8, 95 % CI 2.0–23.1). Subgroup analysis highlighted an excess risk of MALT in patients with gastroduodenal ulcer (OR 5.3, 95 % CI 1.04–23.7) and of AML in patients with rheumatoid arthritis (OR 6.9, 95 % CI 1.2–38.1), and of MDS in subjects exposed to heavy diagnostic X-ray (OR 3.4, 95 % CI 1.03–11.2) when the analysis was restricted to irradiation of pelvis, abdomen, or thorax. Conclusions: Most observed associations confirm results from previous studies. The higher risk of lymphoid malignancies among patients with a history of cholecystectomy needs further investigations.
AB - Purpose: This investigation was aimed at evaluating the association between chronic diseases, medical history and familial cancer, and the risk of developing hematological malignancies. Methods: Data were drawn from a population-based case–control study carried out to assess the risk of non-Hodgkin’s lymphoma and leukemia in an adult population exposed to environmental air pollution in Northern Italy. Each case was classified according to the WHO ICD-O-3 classification. Statistical analyses were performed by multivariable unconditional logistic regression in 573 interviewed subjects (199 lymphoid cases, 95 myeloid cases, and 279 healthy controls). Results: Lymphoid malignancies were associated with a history of gastroduodenal ulcer (OR 2.1, 95 % CI 1.2–3.6), rheumatoid arthritis (OR 4.4, 95 % CI 1.3–19.0), anemia (OR 3.3, 95 % CI 1.2–9.3), cholecystectomy (OR 2.9, 95 % CI 1.0–8.0), heavy diagnostic X-ray exposure (OR 2.1, 95 % CI 1.3–3.7), and a familial risk of non-Hodgkin’s lymphoma (OR 10.1, 95 % CI 1.3–458). Myeloid malignancies were associated with non-neoplastic thyroid diseases (OR 6.2, 95 % CI 1.7–35.6) and anemia (OR 6.8, 95 % CI 2.0–23.1). Subgroup analysis highlighted an excess risk of MALT in patients with gastroduodenal ulcer (OR 5.3, 95 % CI 1.04–23.7) and of AML in patients with rheumatoid arthritis (OR 6.9, 95 % CI 1.2–38.1), and of MDS in subjects exposed to heavy diagnostic X-ray (OR 3.4, 95 % CI 1.03–11.2) when the analysis was restricted to irradiation of pelvis, abdomen, or thorax. Conclusions: Most observed associations confirm results from previous studies. The higher risk of lymphoid malignancies among patients with a history of cholecystectomy needs further investigations.
KW - Arthritis
KW - Case–control study
KW - Familial cancer
KW - Gastroduodenal ulcer
KW - Hematological malignancies
KW - X-ray
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U2 - 10.1007/s10552-015-0592-6
DO - 10.1007/s10552-015-0592-6
M3 - Article
C2 - 25982034
AN - SCOPUS:84930929104
VL - 26
SP - 993
EP - 1002
JO - Cancer Causes and Control
JF - Cancer Causes and Control
SN - 0957-5243
IS - 7
ER -