Chronic effects of subuctaneous interleukin-2 therapy on soluble interleukin-2 receptors in advanced small cell lung cancer

S. Viviani, P. M. Salvini, P. Bidoli, E. Camerini, S. Spinazze, F. Arienti, L. Rivoltini, V. Motta

Research output: Contribution to journalArticle


The increase in IL-2 receptor serum levels is one of the most typical changes in immune parameters during IL-2 cancer immunotherapy. To better define the effects of prolonged IL-2 injerction on SIL-2R levels, we evaluated 7 advanced small cell lung cancer patients who received IL-2 subcutaneously at a daily dose of 9x106 IU/m2/12h for two days followed by 3x106 IU/m2/12h for 18 days (5 days/week for 4 weeks). Moreover, four patients were also evaluated during the second IL-2 cycle. Venous blood samples were drawn before and at weekly intervals during IL-2 therapy. Mean SIL-2R serum levels rapidly increased with the start of IL-2 injection, and they were signicantly higher than the baseline levels throughout the immunotherapy cycle. The increase in mean SIL-2R levels was higher inpatients with progressive disease than in those with response or stable disease, but the difference was not significant. Finally, the increase in mean SIL-2R concentrations during the second IL-2 cycle was not significantly different from that seen during the first one. The present study confirms that IL-2 administration determines an evident increase in SIL-2R levels; moreover, it would demonstrate that re-exposure to IL-2 after a rest period does not induce a more pronounced SI-2R release.

Original languageEnglish
Pages (from-to)21-24
Number of pages4
JournalInternational Journal of Biological Markers
Issue number1
Publication statusPublished - 1993



  • cancer immunotherapy
  • interleukin-2
  • soluble interleukin-2 receptor

ASJC Scopus subject areas

  • Biochemistry
  • Immunology

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