Chronic haemodialysis in small children

a retrospective study of the Italian Pediatric Dialysis Registry

Fabio Paglialonga, Silvia Consolo, Carmine Pecoraro, Enrico Vidal, Bruno Gianoglio, Flora Puteo, Stefano Picca, Maria Teresa Saravo, Alberto Edefonti, Enrico Verrina

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Chronic haemodialysis (HD) in small children has not been adequately investigated. Methods: This was a retrospective investigation of the use of chronic HD in 21 children aged 10 years were analysed. Results: The median age of the 21 children at start of HD was 11.4 [interquartile range (IQR) 6.2–14.6] months, and HD consisted mainly of haemodiafiltration for 3–4 h in ≥4 sessions/week. A total of 51 central venous catheters were placed, and the median survival of tunnelled and temporary lines was 349 and 31 days, respectively (p <0.001). Eight children (38 %) showed evidence of central vein thrombosis. Although 19 % of patients received growth hormone and 63.6 % received enteral feeding, the weight and height of these patients remained suboptimal. During the HD period the haemoglobin level increased in all patients, but not to normal levels (from 8.5 to 9.6 g/dl) despite erythropoietin administration (503–600 U/kg/week). The hospitalisation rate was 1.94/patient-year. Seventeen patients underwent renal transplantation at a median age of 3.0 years. Four patients, all affected by severe comorbidities, died during follow-up (in 2 cases due to absence of a vascular access). The 5- and 10-year cumulative survival was 82.4 and 68.7 %, respectively. Conclusions: Extracorporeal dialysis is feasible in children aged

Original languageEnglish
Pages (from-to)833-841
Number of pages9
JournalPediatric Nephrology
Volume31
Issue number5
DOIs
Publication statusPublished - May 1 2016

Fingerprint

Registries
Renal Dialysis
Dialysis
Retrospective Studies
Pediatrics
Hemodiafiltration
Survival
Central Venous Catheters
Enteral Nutrition
Erythropoietin
Kidney Transplantation
Growth Hormone
Blood Vessels
Comorbidity
Veins
Hemoglobins
Hospitalization
Thrombosis
Weights and Measures

Keywords

  • Central venous catheter
  • Extracorporeal dialysis
  • Haemodiafiltration
  • Paediatric dialysis modality
  • Young children

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Cite this

Chronic haemodialysis in small children : a retrospective study of the Italian Pediatric Dialysis Registry. / Paglialonga, Fabio; Consolo, Silvia; Pecoraro, Carmine; Vidal, Enrico; Gianoglio, Bruno; Puteo, Flora; Picca, Stefano; Saravo, Maria Teresa; Edefonti, Alberto; Verrina, Enrico.

In: Pediatric Nephrology, Vol. 31, No. 5, 01.05.2016, p. 833-841.

Research output: Contribution to journalArticle

Paglialonga, F, Consolo, S, Pecoraro, C, Vidal, E, Gianoglio, B, Puteo, F, Picca, S, Saravo, MT, Edefonti, A & Verrina, E 2016, 'Chronic haemodialysis in small children: a retrospective study of the Italian Pediatric Dialysis Registry', Pediatric Nephrology, vol. 31, no. 5, pp. 833-841. https://doi.org/10.1007/s00467-015-3272-6
Paglialonga, Fabio ; Consolo, Silvia ; Pecoraro, Carmine ; Vidal, Enrico ; Gianoglio, Bruno ; Puteo, Flora ; Picca, Stefano ; Saravo, Maria Teresa ; Edefonti, Alberto ; Verrina, Enrico. / Chronic haemodialysis in small children : a retrospective study of the Italian Pediatric Dialysis Registry. In: Pediatric Nephrology. 2016 ; Vol. 31, No. 5. pp. 833-841.
@article{1c2df5fa8e3542a1a1e69ae192c8dfb5,
title = "Chronic haemodialysis in small children: a retrospective study of the Italian Pediatric Dialysis Registry",
abstract = "Background: Chronic haemodialysis (HD) in small children has not been adequately investigated. Methods: This was a retrospective investigation of the use of chronic HD in 21 children aged 10 years were analysed. Results: The median age of the 21 children at start of HD was 11.4 [interquartile range (IQR) 6.2–14.6] months, and HD consisted mainly of haemodiafiltration for 3–4 h in ≥4 sessions/week. A total of 51 central venous catheters were placed, and the median survival of tunnelled and temporary lines was 349 and 31 days, respectively (p <0.001). Eight children (38 {\%}) showed evidence of central vein thrombosis. Although 19 {\%} of patients received growth hormone and 63.6 {\%} received enteral feeding, the weight and height of these patients remained suboptimal. During the HD period the haemoglobin level increased in all patients, but not to normal levels (from 8.5 to 9.6 g/dl) despite erythropoietin administration (503–600 U/kg/week). The hospitalisation rate was 1.94/patient-year. Seventeen patients underwent renal transplantation at a median age of 3.0 years. Four patients, all affected by severe comorbidities, died during follow-up (in 2 cases due to absence of a vascular access). The 5- and 10-year cumulative survival was 82.4 and 68.7 {\%}, respectively. Conclusions: Extracorporeal dialysis is feasible in children aged",
keywords = "Central venous catheter, Extracorporeal dialysis, Haemodiafiltration, Paediatric dialysis modality, Young children",
author = "Fabio Paglialonga and Silvia Consolo and Carmine Pecoraro and Enrico Vidal and Bruno Gianoglio and Flora Puteo and Stefano Picca and Saravo, {Maria Teresa} and Alberto Edefonti and Enrico Verrina",
year = "2016",
month = "5",
day = "1",
doi = "10.1007/s00467-015-3272-6",
language = "English",
volume = "31",
pages = "833--841",
journal = "Pediatric Nephrology",
issn = "0931-041X",
publisher = "Springer Verlag",
number = "5",

}

TY - JOUR

T1 - Chronic haemodialysis in small children

T2 - a retrospective study of the Italian Pediatric Dialysis Registry

AU - Paglialonga, Fabio

AU - Consolo, Silvia

AU - Pecoraro, Carmine

AU - Vidal, Enrico

AU - Gianoglio, Bruno

AU - Puteo, Flora

AU - Picca, Stefano

AU - Saravo, Maria Teresa

AU - Edefonti, Alberto

AU - Verrina, Enrico

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Background: Chronic haemodialysis (HD) in small children has not been adequately investigated. Methods: This was a retrospective investigation of the use of chronic HD in 21 children aged 10 years were analysed. Results: The median age of the 21 children at start of HD was 11.4 [interquartile range (IQR) 6.2–14.6] months, and HD consisted mainly of haemodiafiltration for 3–4 h in ≥4 sessions/week. A total of 51 central venous catheters were placed, and the median survival of tunnelled and temporary lines was 349 and 31 days, respectively (p <0.001). Eight children (38 %) showed evidence of central vein thrombosis. Although 19 % of patients received growth hormone and 63.6 % received enteral feeding, the weight and height of these patients remained suboptimal. During the HD period the haemoglobin level increased in all patients, but not to normal levels (from 8.5 to 9.6 g/dl) despite erythropoietin administration (503–600 U/kg/week). The hospitalisation rate was 1.94/patient-year. Seventeen patients underwent renal transplantation at a median age of 3.0 years. Four patients, all affected by severe comorbidities, died during follow-up (in 2 cases due to absence of a vascular access). The 5- and 10-year cumulative survival was 82.4 and 68.7 %, respectively. Conclusions: Extracorporeal dialysis is feasible in children aged

AB - Background: Chronic haemodialysis (HD) in small children has not been adequately investigated. Methods: This was a retrospective investigation of the use of chronic HD in 21 children aged 10 years were analysed. Results: The median age of the 21 children at start of HD was 11.4 [interquartile range (IQR) 6.2–14.6] months, and HD consisted mainly of haemodiafiltration for 3–4 h in ≥4 sessions/week. A total of 51 central venous catheters were placed, and the median survival of tunnelled and temporary lines was 349 and 31 days, respectively (p <0.001). Eight children (38 %) showed evidence of central vein thrombosis. Although 19 % of patients received growth hormone and 63.6 % received enteral feeding, the weight and height of these patients remained suboptimal. During the HD period the haemoglobin level increased in all patients, but not to normal levels (from 8.5 to 9.6 g/dl) despite erythropoietin administration (503–600 U/kg/week). The hospitalisation rate was 1.94/patient-year. Seventeen patients underwent renal transplantation at a median age of 3.0 years. Four patients, all affected by severe comorbidities, died during follow-up (in 2 cases due to absence of a vascular access). The 5- and 10-year cumulative survival was 82.4 and 68.7 %, respectively. Conclusions: Extracorporeal dialysis is feasible in children aged

KW - Central venous catheter

KW - Extracorporeal dialysis

KW - Haemodiafiltration

KW - Paediatric dialysis modality

KW - Young children

UR - http://www.scopus.com/inward/record.url?scp=84977527345&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84977527345&partnerID=8YFLogxK

U2 - 10.1007/s00467-015-3272-6

DO - 10.1007/s00467-015-3272-6

M3 - Article

VL - 31

SP - 833

EP - 841

JO - Pediatric Nephrology

JF - Pediatric Nephrology

SN - 0931-041X

IS - 5

ER -