Chronic hepatitis B in children after e antigen seroclearance

Final report of a 29-year longitudinal study

Flavia Bortolotti, Maria Guido, Samuela Bartolacci, Paolo Cadrobbi, Carlo Crivellaro, Franco Noventa, Giulia Morsica, Maria Moriondo, Angelo Gatta

Research output: Contribution to journalArticle

149 Citations (Scopus)

Abstract

Chronic hepatitis B is usually a benign disease in Caucasian children; however, the long-term prognosis remains unsettled. This report describes the results of a 29-year longitudinal study including 99 white children with chronic hepatitis B, mainly acquired horizontally: 91 were hepatitis B e antigen (HBeAg) positive (4 had cirrhosis), and 8 were HBeAg negative at presentation. Of the 91 HBeAg-positive children, 89 underwent HBeAg seroconversion after a mean period of 5.2 ± 4.0 years and were included in the study. Of the 85 children without cirrhosis, one had HBeAg-negative hepatitis and the other 84 became inactive carriers. During a mean follow-up of 14.5 ± 6.1 years after HBeAg seroclearance, 4 carriers experienced reactivation, and 3 of them had HBeAg-negative hepatitis at the last follow-up. Of the 8 initially HBeAg-negative children, 2 had HBeAg-negative hepatitis, and 6 were inactive carriers. Of the 4 children with cirrhosis, 2 had hepatocellular carcinoma (HCC) and remained alive and 2 lost the histological features of cirrhosis in adulthood. Two patients with HBeAg-negative hepatitis and 1 with cirrhosis had experienced drug abuse. At the end of follow-up, 15 of the 89 initially HBeAg-positive patients and 2 of 8 initially HBeAg-negative children had cleared hepatitis B surface antigen. In conclusion, the overall prognosis for chronic hepatitis B in horizontally infected Caucasian children is favorable; however, some patients progress to HCC and HBeAg-negative hepatitis. Long-term monitoring is important, as is counseling on cofactors of liver damage, such as alcohol and drug abuse.

Original languageEnglish
Pages (from-to)556-562
Number of pages7
JournalHepatology
Volume43
Issue number3
DOIs
Publication statusPublished - Mar 2006

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Hepatitis B e Antigens
Chronic Hepatitis B
Longitudinal Studies
Hepatitis
Fibrosis
Substance-Related Disorders
Hepatocellular Carcinoma
Hepatitis B Surface Antigens
Alcoholism
Counseling

ASJC Scopus subject areas

  • Hepatology

Cite this

Bortolotti, F., Guido, M., Bartolacci, S., Cadrobbi, P., Crivellaro, C., Noventa, F., ... Gatta, A. (2006). Chronic hepatitis B in children after e antigen seroclearance: Final report of a 29-year longitudinal study. Hepatology, 43(3), 556-562. https://doi.org/10.1002/hep.21077

Chronic hepatitis B in children after e antigen seroclearance : Final report of a 29-year longitudinal study. / Bortolotti, Flavia; Guido, Maria; Bartolacci, Samuela; Cadrobbi, Paolo; Crivellaro, Carlo; Noventa, Franco; Morsica, Giulia; Moriondo, Maria; Gatta, Angelo.

In: Hepatology, Vol. 43, No. 3, 03.2006, p. 556-562.

Research output: Contribution to journalArticle

Bortolotti, F, Guido, M, Bartolacci, S, Cadrobbi, P, Crivellaro, C, Noventa, F, Morsica, G, Moriondo, M & Gatta, A 2006, 'Chronic hepatitis B in children after e antigen seroclearance: Final report of a 29-year longitudinal study', Hepatology, vol. 43, no. 3, pp. 556-562. https://doi.org/10.1002/hep.21077
Bortolotti F, Guido M, Bartolacci S, Cadrobbi P, Crivellaro C, Noventa F et al. Chronic hepatitis B in children after e antigen seroclearance: Final report of a 29-year longitudinal study. Hepatology. 2006 Mar;43(3):556-562. https://doi.org/10.1002/hep.21077
Bortolotti, Flavia ; Guido, Maria ; Bartolacci, Samuela ; Cadrobbi, Paolo ; Crivellaro, Carlo ; Noventa, Franco ; Morsica, Giulia ; Moriondo, Maria ; Gatta, Angelo. / Chronic hepatitis B in children after e antigen seroclearance : Final report of a 29-year longitudinal study. In: Hepatology. 2006 ; Vol. 43, No. 3. pp. 556-562.
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