Chronic hepatitis B in Italy: New features of an old disease - Approaching the universal prevalence of hepatitis B e antigen-negative cases and the eradication of hepatitis D infection

Evangelista Sagnelli, Tommaso Stroffolini, Alfonso Mele, Michele Imparato, Piero L. Almasio, A. Traverso, A. Arrigoni, M. Torchio, P. Garbagnoli, B. Del Mastro, P. Romano, R. Vanni, D. Brusita, P. Meucci, G. Cassola, M. Borzio, A. Bellobuono, A. De Bona, T. Re, P. Del PoggioO. Baisini, A. Colombo, C. Attolini, D. Sacchini, L. Minoli, V. Gazzaniga, S. Segato, M. Oriolo, A. Parlotto, M. Ghersetti, F. Capra, R. Muratori, C. Sama, S. Boccia, G. Verdianelli, A. Praticò, M. Grandi, E. Ventura, F. Cantoni, A. Vincenti, A. Nerli Alessandro, L. Galeazzi, A. Solinas, M. Paroli, G. M. De Sanctis, S. Sereno, C. Clementi, U. Visco Comandino, A. I. Gallo, D. Festi, G. Sabusco, N. Coppola, C. Scolastico, M. Onofrio, P. Filippini, F. Morisco, A. Liberti, G. Borgia, F. Scarpellino, M. Persico, C. Sagnelli, C. Coppola, L. Caserta, A. Elia, G. De Vita, A. Lanzotti, L. Pizzolante, V. Messina, G. Fiore, E. Agostinacchio, T. Santantonio, M. Mazzola, F. Vinelli, A. Campagna, S. Cataldini, I. Monelli, M. Lascaro, N. Polimeri, P. Frugiuele, M. Ferraro, T. Prestileo, A. Alessandri, M. Russello, P. Bellissima, G. Orifici, G. Pisani, S. Angioini, M. Lai, M. Spanneda

Research output: Contribution to journalArticlepeer-review

Abstract

We evaluated 1336 hepatitis B surface antigen-positive subjects consecutively observed in 79 Italian hospitals over a 6-month period. The proportion of hepatitis B e antigen-negative cases was 86.4%, that of patients coinfected with hepatitis D virus was 9.7%, and the rate of patients coinfected with hepatitis C virus was 16.8%. Multiple logistic regression analysis showed that age >49 years, alcohol abuse, and anti-hepatitis D virus and anti-hepatitis C virus positivity were independent predictors of progression to liver cirrhosis.

Original languageEnglish
Pages (from-to)110-113
Number of pages4
JournalClinical Infectious Diseases
Volume46
Issue number1
DOIs
Publication statusPublished - Jan 1 2008

ASJC Scopus subject areas

  • Immunology

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