Chronic HIV-infected patients show an impaired dendritic cells differentiation of bone marrow CD34+ cells.

Veronica Bordoni; Michele Bibas; Domenico Viola; Alessandra Sacchi; Chiara Agrati; Germana Castelli; Adriana Ammassari; Alessandra Amendola; Isabella Abbate; Federico Martini

Chronic HIV-infected patients show an impaired dendritic cells differentiation of bone marrow CD34+ cells.

Veronica Bordoni, Michele Bibas, Domenico Viola, Alessandra Sacchi, Chiara Agrati, Germana Castelli, Adriana Ammassari, Alessandra Amendola, Isabella Abbate, Federico Martini

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

HIV infection affects dendritic cells (DCs) number, maturation, and function although the cause remains largely unknown. Purified CD34⁺ hematopoietic progenitor cells (HPCs) obtained from bone marrow of chronic HIV-infected patients were investigated for the differentiative capability toward mature DCs. HIV, although not in active replication, was found able to impair CD34⁺ HPC differentiation into mature DCs. These results suggest that DCs impairment found in HIV-infected patients may be related to a failure by bone marrow CD34 HPCs to produce an adequate number of DCs.

Original language	English
Pages (from-to)	342-344
Number of pages	3
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	64
Issue number	4
Publication status	Published - Dec 1 2013

ASJC Scopus subject areas

Medicine(all)

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Chronic HIV-infected patients show an impaired dendritic cells differentiation of bone marrow CD34+ cells. / Bordoni, Veronica ; Bibas, Michele; Viola, Domenico; Sacchi, Alessandra ; Agrati, Chiara; Castelli, Germana; Ammassari, Adriana ; Amendola, Alessandra ; Abbate, Isabella ; Martini, Federico.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 64, No. 4, 01.12.2013, p. 342-344.

Research output: Contribution to journal › Article › peer-review

Bordoni, Veronica ; Bibas, Michele ; Viola, Domenico ; Sacchi, Alessandra ; Agrati, Chiara ; Castelli, Germana ; Ammassari, Adriana ; Amendola, Alessandra ; Abbate, Isabella ; Martini, Federico. / Chronic HIV-infected patients show an impaired dendritic cells differentiation of bone marrow CD34+ cells. In: Journal of Acquired Immune Deficiency Syndromes. 2013 ; Vol. 64, No. 4. pp. 342-344.

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AU - Agrati, Chiara

AU - Castelli, Germana

AU - Ammassari, Adriana

AU - Amendola, Alessandra

AU - Abbate, Isabella

AU - Martini, Federico

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AB - HIV infection affects dendritic cells (DCs) number, maturation, and function although the cause remains largely unknown. Purified CD34+ hematopoietic progenitor cells (HPCs) obtained from bone marrow of chronic HIV-infected patients were investigated for the differentiative capability toward mature DCs. HIV, although not in active replication, was found able to impair CD34+ HPC differentiation into mature DCs. These results suggest that DCs impairment found in HIV-infected patients may be related to a failure by bone marrow CD34 HPCs to produce an adequate number of DCs.

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