Abstract
HIV infection affects dendritic cells (DCs) number, maturation, and function although the cause remains largely unknown. Purified CD34+ hematopoietic progenitor cells (HPCs) obtained from bone marrow of chronic HIV-infected patients were investigated for the differentiative capability toward mature DCs. HIV, although not in active replication, was found able to impair CD34+ HPC differentiation into mature DCs. These results suggest that DCs impairment found in HIV-infected patients may be related to a failure by bone marrow CD34 HPCs to produce an adequate number of DCs.
| Original language | English |
|---|---|
| Pages (from-to) | 342-344 |
| Number of pages | 3 |
| Journal | Journal of Acquired Immune Deficiency Syndromes |
| Volume | 64 |
| Issue number | 4 |
| Publication status | Published - Dec 1 2013 |
Fingerprint
ASJC Scopus subject areas
- Medicine(all)
Cite this
Bordoni, V., Bibas, M., Viola, D., Sacchi, A., Agrati, C., Castelli, G., Ammassari, A., Amendola, A., Abbate, I., & Martini, F. (2013). Chronic HIV-infected patients show an impaired dendritic cells differentiation of bone marrow CD34+ cells. Journal of Acquired Immune Deficiency Syndromes, 64(4), 342-344.