TY - JOUR
T1 - Chronic HIV-infected patients show an impaired dendritic cells differentiation of bone marrow CD34+ cells.
AU - Bordoni, Veronica
AU - Bibas, Michele
AU - Viola, Domenico
AU - Sacchi, Alessandra
AU - Agrati, Chiara
AU - Castelli, Germana
AU - Ammassari, Adriana
AU - Amendola, Alessandra
AU - Abbate, Isabella
AU - Martini, Federico
PY - 2013/12/1
Y1 - 2013/12/1
N2 - HIV infection affects dendritic cells (DCs) number, maturation, and function although the cause remains largely unknown. Purified CD34+ hematopoietic progenitor cells (HPCs) obtained from bone marrow of chronic HIV-infected patients were investigated for the differentiative capability toward mature DCs. HIV, although not in active replication, was found able to impair CD34+ HPC differentiation into mature DCs. These results suggest that DCs impairment found in HIV-infected patients may be related to a failure by bone marrow CD34 HPCs to produce an adequate number of DCs.
AB - HIV infection affects dendritic cells (DCs) number, maturation, and function although the cause remains largely unknown. Purified CD34+ hematopoietic progenitor cells (HPCs) obtained from bone marrow of chronic HIV-infected patients were investigated for the differentiative capability toward mature DCs. HIV, although not in active replication, was found able to impair CD34+ HPC differentiation into mature DCs. These results suggest that DCs impairment found in HIV-infected patients may be related to a failure by bone marrow CD34 HPCs to produce an adequate number of DCs.
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M3 - Article
C2 - 24169119
AN - SCOPUS:84891684738
VL - 64
SP - 342
EP - 344
JO - Journal of Acquired Immune Deficiency Syndromes
JF - Journal of Acquired Immune Deficiency Syndromes
SN - 1525-4135
IS - 4
ER -