Chronic HIV-infected patients show an impaired dendritic cells differentiation of bone marrow CD34+ cells.

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Abstract

HIV infection affects dendritic cells (DCs) number, maturation, and function although the cause remains largely unknown. Purified CD34+ hematopoietic progenitor cells (HPCs) obtained from bone marrow of chronic HIV-infected patients were investigated for the differentiative capability toward mature DCs. HIV, although not in active replication, was found able to impair CD34+ HPC differentiation into mature DCs. These results suggest that DCs impairment found in HIV-infected patients may be related to a failure by bone marrow CD34 HPCs to produce an adequate number of DCs.

Original languageEnglish
Pages (from-to)342-344
Number of pages3
JournalJournal of Acquired Immune Deficiency Syndromes
Volume64
Issue number4
Publication statusPublished - Dec 1 2013

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ASJC Scopus subject areas

  • Medicine(all)

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