Chronic hypertension induced by ouabain but not digoxin in the rat: Antihypertensive effect of digoxin and digitoxin

P. Manunta, J. Hamilton, A. C. Rogowski, B. P. Hamilton, J. M. Hamlyn

Research output: Contribution to journalArticle

Abstract

Elevated circulating levels of an endogenous ouabain (EO) have been associated with essential hypertension. To investigate structure-activity relationships relevant to blood pressure, we infused either ouabain, ouabagenin, digoxin or digitoxin at 30 μg/kg/day in normal Sprague Dawley rats. After five weeks, the ouabain and ouabagenin infused rats were hypertensive, whereas blood pressures declined below their vehicle controls in rats infused with digoxin or digitoxin. In a second study, mean blood pressures were 118.5 ±1.7 mmHg in rats infused with ouabain (15 μg/kg/day) on day 35 vs. 98.3±1.8 and 100.3±1.1 mmHg in the digoxin (30 μg/kg/day) and vehicle infused groups (both p

Original languageEnglish
JournalHypertension Research
Volume23
Issue numberSUPPL.
Publication statusPublished - 2000

Keywords

  • Blood pressure
  • Cardiac glycosides
  • Endogenous
  • Kidney
  • Sodium pump

ASJC Scopus subject areas

  • Internal Medicine

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