Chronic idiopathic myelofibrosis: Independent prognostic importance of bone marrow microvascular density evaluated by CD105 (endoglin) immunostaining

Maurilio Ponzoni, David G. Savage, A. J M Ferreri, Giancarlo Pruneri, Giuseppe Viale, Paolo Servida, Francesco Bertolini, Attilio Orazi

Research output: Contribution to journalArticlepeer-review

Abstract

Microvascular density (MVD) is substantially increased in bone marrow biopsies of patients with chronic idiopathic myelofibrosis (CIMF). CD105, a useful molecule for assessing MVD in various malignancies, is preferentially expressed by recently formed microvessels. Increased serum-soluble CD105 in patients with chronic myeloproliferative disorders, including CIMF, was documented. CD105 MVD has not so far been investigated in CIMF: to this end, the results in 55 patients with CIMF and 21 controls were compared with the conventional CD34 immunostaining as well as traditional histological and clinical disease features. The MVD mean values estimated by both CD105 and CD34 were significantly higher in CIMF patients than in controls (P2 correlated with increased CD105 MVD (P=0.05). A multivariate analysis confirmed that CD105-positive MVD was an independent adverse prognosticator. This study demonstrates that while MVD, as assessed by both CD34 and CD105 immunostaining, is significantly increased in CIMF, only CD105-determined MVD correlates with the degree of fibrosis and is prognostically relevant. These findings provide a rationale for the investigational use of anti-CD105-targeted drugs in CIMF.

Original languageEnglish
Pages (from-to)1513-1520
Number of pages8
JournalModern Pathology
Volume17
Issue number12
DOIs
Publication statusPublished - Dec 2004

Keywords

  • Bone marrow
  • CD105
  • Endoglin
  • Myelofibrosis
  • Prognosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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