Chronic immune-related demyelinating neuropathies

R. Nemni, M. Sessa

Research output: Contribution to journalArticle

Abstract

In recent years many important advances have been made in the knowledge of the mechanisms that may produce peripheral nerve damage. Data in the literature indicate that in some chronic demyelinating neuropathy autoantibodies against myelin antigens may play a pathogenic role. The pathogenic role of T cells, cytokines, complement, and class II molecules has also been studied. Identification of specific immune-related demyelinating polyneuropathies provides clues to future therapeutic approaches. This paper focuses on the chronic inflammatory demyelinating polyneuropathy, chronic demyelinating neuropathies associated with monoclonal gammapathies of undetermined significance, and multifocal motor neuropathy, and reviews their clinical, patophysiological and immunological features.

Original languageEnglish
Pages (from-to)177-185
Number of pages9
JournalEuropean Journal of Neurology
Volume3
Issue number3
Publication statusPublished - 1996

Fingerprint

Monoclonal Gammopathy of Undetermined Significance
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Polyneuropathies
Myelin Sheath
Peripheral Nerves
Autoantibodies
Cytokines
T-Lymphocytes
Antigens
Therapeutics

Keywords

  • Antibodies
  • Autoimmune
  • Demyelination
  • Myelin
  • Neuropathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Chronic immune-related demyelinating neuropathies. / Nemni, R.; Sessa, M.

In: European Journal of Neurology, Vol. 3, No. 3, 1996, p. 177-185.

Research output: Contribution to journalArticle

Nemni, R & Sessa, M 1996, 'Chronic immune-related demyelinating neuropathies', European Journal of Neurology, vol. 3, no. 3, pp. 177-185.
Nemni, R. ; Sessa, M. / Chronic immune-related demyelinating neuropathies. In: European Journal of Neurology. 1996 ; Vol. 3, No. 3. pp. 177-185.
@article{76c202fa92014e98b406246260dd537d,
title = "Chronic immune-related demyelinating neuropathies",
abstract = "In recent years many important advances have been made in the knowledge of the mechanisms that may produce peripheral nerve damage. Data in the literature indicate that in some chronic demyelinating neuropathy autoantibodies against myelin antigens may play a pathogenic role. The pathogenic role of T cells, cytokines, complement, and class II molecules has also been studied. Identification of specific immune-related demyelinating polyneuropathies provides clues to future therapeutic approaches. This paper focuses on the chronic inflammatory demyelinating polyneuropathy, chronic demyelinating neuropathies associated with monoclonal gammapathies of undetermined significance, and multifocal motor neuropathy, and reviews their clinical, patophysiological and immunological features.",
keywords = "Antibodies, Autoimmune, Demyelination, Myelin, Neuropathy",
author = "R. Nemni and M. Sessa",
year = "1996",
language = "English",
volume = "3",
pages = "177--185",
journal = "European Journal of Neurology",
issn = "1351-5101",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "3",

}

TY - JOUR

T1 - Chronic immune-related demyelinating neuropathies

AU - Nemni, R.

AU - Sessa, M.

PY - 1996

Y1 - 1996

N2 - In recent years many important advances have been made in the knowledge of the mechanisms that may produce peripheral nerve damage. Data in the literature indicate that in some chronic demyelinating neuropathy autoantibodies against myelin antigens may play a pathogenic role. The pathogenic role of T cells, cytokines, complement, and class II molecules has also been studied. Identification of specific immune-related demyelinating polyneuropathies provides clues to future therapeutic approaches. This paper focuses on the chronic inflammatory demyelinating polyneuropathy, chronic demyelinating neuropathies associated with monoclonal gammapathies of undetermined significance, and multifocal motor neuropathy, and reviews their clinical, patophysiological and immunological features.

AB - In recent years many important advances have been made in the knowledge of the mechanisms that may produce peripheral nerve damage. Data in the literature indicate that in some chronic demyelinating neuropathy autoantibodies against myelin antigens may play a pathogenic role. The pathogenic role of T cells, cytokines, complement, and class II molecules has also been studied. Identification of specific immune-related demyelinating polyneuropathies provides clues to future therapeutic approaches. This paper focuses on the chronic inflammatory demyelinating polyneuropathy, chronic demyelinating neuropathies associated with monoclonal gammapathies of undetermined significance, and multifocal motor neuropathy, and reviews their clinical, patophysiological and immunological features.

KW - Antibodies

KW - Autoimmune

KW - Demyelination

KW - Myelin

KW - Neuropathy

UR - http://www.scopus.com/inward/record.url?scp=0029882255&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029882255&partnerID=8YFLogxK

M3 - Article

C2 - 21284767

AN - SCOPUS:0029882255

VL - 3

SP - 177

EP - 185

JO - European Journal of Neurology

JF - European Journal of Neurology

SN - 1351-5101

IS - 3

ER -