Chronic immune-related demyelinating neuropathies

R. Nemni, M. Sessa

Research output: Contribution to journalArticlepeer-review


In recent years many important advances have been made in the knowledge of the mechanisms that may produce peripheral nerve damage. Data in the literature indicate that in some chronic demyelinating neuropathy autoantibodies against myelin antigens may play a pathogenic role. The pathogenic role of T cells, cytokines, complement, and class II molecules has also been studied. Identification of specific immune-related demyelinating polyneuropathies provides clues to future therapeutic approaches. This paper focuses on the chronic inflammatory demyelinating polyneuropathy, chronic demyelinating neuropathies associated with monoclonal gammapathies of undetermined significance, and multifocal motor neuropathy, and reviews their clinical, patophysiological and immunological features.

Original languageEnglish
Pages (from-to)177-185
Number of pages9
JournalEuropean Journal of Neurology
Issue number3
Publication statusPublished - 1996


  • Antibodies
  • Autoimmune
  • Demyelination
  • Myelin
  • Neuropathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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