Chronic infection with chlamydia pneumoniae is related to the severity of asthma

P. N. Black, R. Scicchitano, C. R. Jenkins, F. Blasi, L. Allegra, J. Wlodarczyk, B. C. Cooper

Research output: Contribution to journalArticlepeer-review

Abstract

We are conducting a double-blind, controlled trial of roxithromycin in subjects with asthma and high titres of antibody to C. pneumoniae. We have examined the association between the titre of antibody to C. pneumoniae and severity of asthma in the subjects screened for this study in Australia and New Zealand. Subjects were 18-60 years in age. At screening subjects were asked about symptoms and use of asthma medicines. If the subjects had IgG antibodies to C. pneumoniae a 1:64 and/or IgA antibodies a 1:16 and their FEV. was 50-90% of predicted; they were asked to record their PEFR and symptom scores twice daily on a diary card for 4 weeks. Subjects were classified as being on high dose inhaled steroids if they used 22000jj.g/d of beclomethasone dipropionate (BDP) and low dose inhaled steroids with

Original languageEnglish
JournalRespirology
Volume4
Issue numberSUPPL. 1
Publication statusPublished - 1999

Keywords

  • Asthma
  • C. Pneumoniae
  • IgA antibodies
  • Inhaled steroids

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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