Chronic inflammation and extra-nodal marginal-zone lymphomas of MALT-type

Catherine Thieblemont, Francesco Bertoni, Christiane Copie-Bergman, Andrés J M Ferreri, Maurilio Ponzoni

Research output: Contribution to journalArticle

Abstract

Extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT) is an indolent B-cell non-Hodgkin lymphoma (NHL) arising in lymphoid populations that are induced by chronic inflammation in extra nodal sites. The stomach is the most commonly affected organ, and MALT lymphoma is clearly associated with a gastroduodenitis induced by a microbial pathogen, Helicobacter pylori, thus gastric MALT lymphoma represents a paradigm for evaluating inflammatory-associated lymphomagenesis. Variable levels of evidence have indicated a possible association between other microorganisms and non-gastric MALT lymphomas. In addition to infectious etiology, chronic inflammation arising as a result of autoimmune diseases such as Sjogren's syndrome or Hashimoto thyroiditis, poses a significant risk factor for developing NHL. Recently, genetic alterations affecting the NF-κB pathway, a major signaling pathway involved in many cancers, have been identified in MALT lymphoma. This review will present MALT lymphoma as an example of the close pathogenetic link between chronic microenvironmental inflammation and tumor development, showing how these observations can be integrated into daily clinical practice, also in terms of therapeutic implications, with particular focus on the NF-κB pathway.

Original languageEnglish
Pages (from-to)33-42
Number of pages10
JournalSeminars in Cancer Biology
Volume24
DOIs
Publication statusPublished - 2014

Fingerprint

Marginal Zone B-Cell Lymphoma
Inflammation
Non-Hodgkin's Lymphoma
Hashimoto Disease
Sjogren's Syndrome
B-Cell Lymphoma
Gastric Mucosa
Helicobacter pylori
Autoimmune Diseases
Neoplasms
Stomach
Population

Keywords

  • Chronic inflammation
  • MALT lymphoma
  • Marginal zone
  • Microbial pathogen autoimmune disease

ASJC Scopus subject areas

  • Cancer Research

Cite this

Chronic inflammation and extra-nodal marginal-zone lymphomas of MALT-type. / Thieblemont, Catherine; Bertoni, Francesco; Copie-Bergman, Christiane; Ferreri, Andrés J M; Ponzoni, Maurilio.

In: Seminars in Cancer Biology, Vol. 24, 2014, p. 33-42.

Research output: Contribution to journalArticle

Thieblemont, Catherine ; Bertoni, Francesco ; Copie-Bergman, Christiane ; Ferreri, Andrés J M ; Ponzoni, Maurilio. / Chronic inflammation and extra-nodal marginal-zone lymphomas of MALT-type. In: Seminars in Cancer Biology. 2014 ; Vol. 24. pp. 33-42.
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