Chronic inflammation and sarcopenia: A regenerative cell therapy perspective

Jagadish K. Chhetri, Philipe de Souto Barreto, Bertrand Fougère, Yves Rolland, Bruno Vellas, Matteo Cesari

Research output: Contribution to journalShort surveypeer-review

Abstract

Sarcopenia is characterized by reduced skeletal muscle mass and strength in older individuals. It is one of the leading cause of physical limitation in older adults, and associated with wide spectrum of adverse events including disability and mortality. The phenomenon of chronic-inflammation or inflamm-aging with aging is known to be a major contributor to myriad of geriatric conditions including sarcopenia. Recent advances in regenerative medicine, in particular cell therapy have opened up new possibilities to ameliorate broad range of inflammatory disorders. In this context, we will discuss on possibilities of modulation of the chronic-inflammatory activation in older adults using regenerative cell therapy strategies. This review is an effort toward reducing the growing burden of sarcopenia related disability and dependency in the aging population.

Original languageEnglish
Pages (from-to)115-123
Number of pages9
JournalExperimental Gerontology
Volume103
DOIs
Publication statusPublished - Mar 1 2018

Keywords

  • Aging
  • Cell therapy
  • Chronic inflammation
  • Inflamm-aging
  • Mesenchymal stem cells
  • Mesenchymal stromal cells
  • Regenerative medicine
  • Sarcopenia
  • Stem cells

ASJC Scopus subject areas

  • Biochemistry
  • Ageing
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

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