Chronic inflammatory demyelinating polyneuropathy of childhood: Clinical and neuroradiological findings

D. P. Rossi, L. Doria Lamba, A. Pistorio, M. Pedemonte, E. Veneselli, A. Rossi

Research output: Contribution to journalArticlepeer-review


Introduction: This study aims to report on serial magnetic resonance imaging (MRI) studies and clinical features in a cohort of children with chronic inflammatory demyelinating polyneuropathy (CIDP). Methods: Clinical, neuroradiological, and statistical investigations performed on nine children with CIDP were retrospectively reviewed. Pathological nerve root enhancement was categorized according to severity, extension, and morphology. A MRI score was thus obtained, and correlations with the clinical picture and disease course were explored. Results: Intrathecal nerve root enhancement (NRE) of varying degrees was seen in a high percentage of patients. There was no significant correlation between the total MRI score at the first MRI study and either severity or course of the disease. However, we found a significant difference (p = 0.002) in NRE of patients with improving CIDP with respect to those with stable or progressing disease at the time of follow-up MRI. Conclusion: Contrast-enhanced MRI plays a pivotal role in children with CIDP, both for the initial diagnosis as well as a biomarker of clinical evolution, and should be performed in all children with suspected CIDP both at initial presentation and during follow-up. Further multicenter studies on larger cohorts are awaited to determine the ideal timing for follow-up MRI.

Original languageEnglish
Pages (from-to)1233-1239
Number of pages7
Issue number10
Publication statusPublished - Oct 2013


  • Childhood
  • Chronic inflammatory demyelinating polyneuropathy
  • Neuroimaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


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