TY - JOUR
T1 - Chronic inflammatory demyelinating polyradiculoneuropathy
T2 - Long-term course and treatment of 60 patients
AU - Sghirlanzoni, A.
AU - Solari, A.
AU - Ciano, C.
AU - Mariotti, C.
AU - Fallica, E.
AU - Pareyson, D.
PY - 2000
Y1 - 2000
N2 - The objective of this study was to asess the long-term course and treament of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). We avaluated, according to a predefined protocol, a series of 60 CIDP patients who recieved a long-term course of steroids and immunosuppressants. Eighteen of then also had monoclonal gammopathy of undetermined significance (MGUS). Mean follow-up was 4.4 years and was similar to CIDP and CIDP-MGUS patients. At the end of the follow-up, improvement was ascertained in 60% of patients (69% CIDP, 39% CIDP-MGUS). Complete remission was achieved in 13%. Out of 26 patients receiving steroids as a monotherapy, 19 improved (73%). The following variables were predictive of better outcome: female gender, younger age at onset, replasing-remitting course, and absence of axonal damage at neurophysiologic study. In the multivariate analysis, younger age at onset and demyclination without axonal damage still retained an independent positive value.
AB - The objective of this study was to asess the long-term course and treament of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). We avaluated, according to a predefined protocol, a series of 60 CIDP patients who recieved a long-term course of steroids and immunosuppressants. Eighteen of then also had monoclonal gammopathy of undetermined significance (MGUS). Mean follow-up was 4.4 years and was similar to CIDP and CIDP-MGUS patients. At the end of the follow-up, improvement was ascertained in 60% of patients (69% CIDP, 39% CIDP-MGUS). Complete remission was achieved in 13%. Out of 26 patients receiving steroids as a monotherapy, 19 improved (73%). The following variables were predictive of better outcome: female gender, younger age at onset, replasing-remitting course, and absence of axonal damage at neurophysiologic study. In the multivariate analysis, younger age at onset and demyclination without axonal damage still retained an independent positive value.
KW - Chronic inflammatory demyelinating polyradiculoneuropathy
KW - CIDP
KW - Dysimmune neuropathy
KW - MGUS
KW - Plasmapheresis
KW - Steroids
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U2 - 10.1007/s100720070116
DO - 10.1007/s100720070116
M3 - Article
C2 - 10938200
AN - SCOPUS:0033946908
VL - 21
SP - 31
EP - 37
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 1
ER -