Chronic inflammatory demyelinating polyradiculoneuropathy: Long-term course and treatment of 60 patients

A. Sghirlanzoni, A. Solari, C. Ciano, C. Mariotti, E. Fallica, D. Pareyson

Research output: Contribution to journalArticlepeer-review

Abstract

The objective of this study was to asess the long-term course and treament of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). We avaluated, according to a predefined protocol, a series of 60 CIDP patients who recieved a long-term course of steroids and immunosuppressants. Eighteen of then also had monoclonal gammopathy of undetermined significance (MGUS). Mean follow-up was 4.4 years and was similar to CIDP and CIDP-MGUS patients. At the end of the follow-up, improvement was ascertained in 60% of patients (69% CIDP, 39% CIDP-MGUS). Complete remission was achieved in 13%. Out of 26 patients receiving steroids as a monotherapy, 19 improved (73%). The following variables were predictive of better outcome: female gender, younger age at onset, replasing-remitting course, and absence of axonal damage at neurophysiologic study. In the multivariate analysis, younger age at onset and demyclination without axonal damage still retained an independent positive value.

Original languageEnglish
Pages (from-to)31-37
Number of pages7
JournalNeurological Sciences
Volume21
Issue number1
DOIs
Publication statusPublished - 2000

Keywords

  • Chronic inflammatory demyelinating polyradiculoneuropathy
  • CIDP
  • Dysimmune neuropathy
  • MGUS
  • Plasmapheresis
  • Steroids

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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