TY - JOUR
T1 - Chronic inhibition of bradykinin B2-receptors enhances the slow vasopressor response to angiotensin II
AU - Madeddu, Paolo
AU - Parpaglia, Paolo Pinna
AU - Demontis, Maria Piera
AU - Varoni, Maria Vittoria
AU - Fattaccio, Maria Caterina
AU - Glorioso, Nicola
PY - 1994/5
Y1 - 1994/5
N2 - The contribution of endogenous kinins in the regulation of blood pressure of angiotensin-treated rats was evaluated using the new bradykinin B2- receptor antagonist Hoe 140 (D-Arg,[Hyp3, Thi5, D-Tic7, Oic8]- bradykinin). Chronic infusion of Hoe 140 at 75 nmol/d (a dose able to inhibit the vasodepressor effect of an intra-aortic bolus injection of 0.85 nmol/kg bradykinin) did not alter systolic blood pressure (tail-cuff plethysmography). Chronic infusion of angiotensin II (Ang II) induced a dose- related increase in systolic blood pressure and plasma Ang II levels. The vasopressor effect of 40 or 100 nmol/d Ang II was enhanced in rats given chronic infusion of Hoe 140 (by 12 and 14 mm Hg, respectively), whereas the increase in plasma Ang II levels remained unaltered. Furthermore, a low nonpressor dose of Ang II (20 nmol/d) was then able to increase blood pressure during chronic blockade of bradykinin receptors by Hoe 140 (from 126±3 to 137±3 mm Hg, P2-receptors enhances the slow pressor effect induced by moderate to severe increases in circulating Ang II levels. Therefore, endogenous kinins may play a role in preventing the chronic pressure effect of an excess of Ang II.
AB - The contribution of endogenous kinins in the regulation of blood pressure of angiotensin-treated rats was evaluated using the new bradykinin B2- receptor antagonist Hoe 140 (D-Arg,[Hyp3, Thi5, D-Tic7, Oic8]- bradykinin). Chronic infusion of Hoe 140 at 75 nmol/d (a dose able to inhibit the vasodepressor effect of an intra-aortic bolus injection of 0.85 nmol/kg bradykinin) did not alter systolic blood pressure (tail-cuff plethysmography). Chronic infusion of angiotensin II (Ang II) induced a dose- related increase in systolic blood pressure and plasma Ang II levels. The vasopressor effect of 40 or 100 nmol/d Ang II was enhanced in rats given chronic infusion of Hoe 140 (by 12 and 14 mm Hg, respectively), whereas the increase in plasma Ang II levels remained unaltered. Furthermore, a low nonpressor dose of Ang II (20 nmol/d) was then able to increase blood pressure during chronic blockade of bradykinin receptors by Hoe 140 (from 126±3 to 137±3 mm Hg, P2-receptors enhances the slow pressor effect induced by moderate to severe increases in circulating Ang II levels. Therefore, endogenous kinins may play a role in preventing the chronic pressure effect of an excess of Ang II.
KW - angiotensins
KW - blood pressure
KW - bradykinin
KW - kallikrein
KW - mineralocorticoids
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M3 - Article
C2 - 8175175
AN - SCOPUS:0028300307
VL - 23
SP - 646
EP - 652
JO - Hypertension
JF - Hypertension
SN - 0194-911X
IS - 5
ER -