Chronic intestinal inflammation and seronegative spondyloarthropathy in children

F. Conti, O. Borrelli, C. Anania, E. Marocchi, E. F. Romeo, M. Paganelli, G. Valesini, S. Cucchiara

Research output: Contribution to journalArticle

Abstract

Background.: Spondyloarthropathy in adults has been shown to be associated with either clinical or subclinical intestinal inflammation, however this association has rarely been described in children. Aim.: To report paediatric patients primarily referred to a paediatric gastroenterology centre for suspected inflammatory bowel disease and found to be affected by a seronegative spondyloarthropathy. Intestinal inflammatory lesions and rheumatological features have been described in them. Subjects.: During a 18-month period, 129 children were referred because of symptoms and signs suggesting an inflammatory bowel disease; 31 of them (range age: 5-17 years) were selected because they also had signs of axial and/or peripheral arthropathy and form the basis of our study. Methods.: The investigated patients underwent ileo-colonoscopy with biopsy and rheumatological assessment that also included X-ray and magnetic resonance imaging of the sacroiliac joints. Results.: Only seven children had a classical inflammatory bowel disease (four had ulcerative colitis, three had Crohn's disease), 12 had an indeterminate colitis, 12 a lymphoid nodular hyperplasia of the distal ileum as main feature. In the latter two groups, endoscopy and histology revealed an intestinal inflammation of chronic type distinct from the classical pattern found in inflammatory bowel disease. All were HLA B27 negative and fulfilled the European Spondyloarthropathy Study Group criteria for spondyloarthropathy (except five children classified as undifferentiated spondyloarthropathy). Conclusions.: In a group of children primarily investigated for suspected inflammatory bowel disease and also presenting a seronegative spondyloarthropathy we have described both intestinal and rheumatological features. The majority of them exhibited either an indeterminate colitis or a lymphoid nodular hyperplasia of the distal ileum as main feature. These patients may be a population at risk of developing a full inflammatory bowel disease phenotype.

Original languageEnglish
Pages (from-to)761-767
Number of pages7
JournalDigestive and Liver Disease
Volume37
Issue number10
DOIs
Publication statusPublished - Oct 2005

Fingerprint

Spondylarthropathies
Inflammatory Bowel Diseases
Inflammation
Colitis
Ileum
Hyperplasia
Pediatrics
Sacroiliac Joint
HLA-B27 Antigen
Joint Diseases
Gastroenterology
Colonoscopy
Ulcerative Colitis
Crohn Disease
Endoscopy
Signs and Symptoms
Histology
Magnetic Resonance Imaging
X-Rays
Phenotype

Keywords

  • Inflammatory bowel disease
  • Lymphoid nodular hyperplasia (LNH)
  • Paediatrics
  • Spondyloarthropathy

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Conti, F., Borrelli, O., Anania, C., Marocchi, E., Romeo, E. F., Paganelli, M., ... Cucchiara, S. (2005). Chronic intestinal inflammation and seronegative spondyloarthropathy in children. Digestive and Liver Disease, 37(10), 761-767. https://doi.org/10.1016/j.dld.2005.04.028

Chronic intestinal inflammation and seronegative spondyloarthropathy in children. / Conti, F.; Borrelli, O.; Anania, C.; Marocchi, E.; Romeo, E. F.; Paganelli, M.; Valesini, G.; Cucchiara, S.

In: Digestive and Liver Disease, Vol. 37, No. 10, 10.2005, p. 761-767.

Research output: Contribution to journalArticle

Conti, F, Borrelli, O, Anania, C, Marocchi, E, Romeo, EF, Paganelli, M, Valesini, G & Cucchiara, S 2005, 'Chronic intestinal inflammation and seronegative spondyloarthropathy in children', Digestive and Liver Disease, vol. 37, no. 10, pp. 761-767. https://doi.org/10.1016/j.dld.2005.04.028
Conti, F. ; Borrelli, O. ; Anania, C. ; Marocchi, E. ; Romeo, E. F. ; Paganelli, M. ; Valesini, G. ; Cucchiara, S. / Chronic intestinal inflammation and seronegative spondyloarthropathy in children. In: Digestive and Liver Disease. 2005 ; Vol. 37, No. 10. pp. 761-767.
@article{8e41d782326a4b73b451e2a9e46dcdfa,
title = "Chronic intestinal inflammation and seronegative spondyloarthropathy in children",
abstract = "Background.: Spondyloarthropathy in adults has been shown to be associated with either clinical or subclinical intestinal inflammation, however this association has rarely been described in children. Aim.: To report paediatric patients primarily referred to a paediatric gastroenterology centre for suspected inflammatory bowel disease and found to be affected by a seronegative spondyloarthropathy. Intestinal inflammatory lesions and rheumatological features have been described in them. Subjects.: During a 18-month period, 129 children were referred because of symptoms and signs suggesting an inflammatory bowel disease; 31 of them (range age: 5-17 years) were selected because they also had signs of axial and/or peripheral arthropathy and form the basis of our study. Methods.: The investigated patients underwent ileo-colonoscopy with biopsy and rheumatological assessment that also included X-ray and magnetic resonance imaging of the sacroiliac joints. Results.: Only seven children had a classical inflammatory bowel disease (four had ulcerative colitis, three had Crohn's disease), 12 had an indeterminate colitis, 12 a lymphoid nodular hyperplasia of the distal ileum as main feature. In the latter two groups, endoscopy and histology revealed an intestinal inflammation of chronic type distinct from the classical pattern found in inflammatory bowel disease. All were HLA B27 negative and fulfilled the European Spondyloarthropathy Study Group criteria for spondyloarthropathy (except five children classified as undifferentiated spondyloarthropathy). Conclusions.: In a group of children primarily investigated for suspected inflammatory bowel disease and also presenting a seronegative spondyloarthropathy we have described both intestinal and rheumatological features. The majority of them exhibited either an indeterminate colitis or a lymphoid nodular hyperplasia of the distal ileum as main feature. These patients may be a population at risk of developing a full inflammatory bowel disease phenotype.",
keywords = "Inflammatory bowel disease, Lymphoid nodular hyperplasia (LNH), Paediatrics, Spondyloarthropathy",
author = "F. Conti and O. Borrelli and C. Anania and E. Marocchi and Romeo, {E. F.} and M. Paganelli and G. Valesini and S. Cucchiara",
year = "2005",
month = "10",
doi = "10.1016/j.dld.2005.04.028",
language = "English",
volume = "37",
pages = "761--767",
journal = "Digestive and Liver Disease",
issn = "1590-8658",
publisher = "Elsevier B.V.",
number = "10",

}

TY - JOUR

T1 - Chronic intestinal inflammation and seronegative spondyloarthropathy in children

AU - Conti, F.

AU - Borrelli, O.

AU - Anania, C.

AU - Marocchi, E.

AU - Romeo, E. F.

AU - Paganelli, M.

AU - Valesini, G.

AU - Cucchiara, S.

PY - 2005/10

Y1 - 2005/10

N2 - Background.: Spondyloarthropathy in adults has been shown to be associated with either clinical or subclinical intestinal inflammation, however this association has rarely been described in children. Aim.: To report paediatric patients primarily referred to a paediatric gastroenterology centre for suspected inflammatory bowel disease and found to be affected by a seronegative spondyloarthropathy. Intestinal inflammatory lesions and rheumatological features have been described in them. Subjects.: During a 18-month period, 129 children were referred because of symptoms and signs suggesting an inflammatory bowel disease; 31 of them (range age: 5-17 years) were selected because they also had signs of axial and/or peripheral arthropathy and form the basis of our study. Methods.: The investigated patients underwent ileo-colonoscopy with biopsy and rheumatological assessment that also included X-ray and magnetic resonance imaging of the sacroiliac joints. Results.: Only seven children had a classical inflammatory bowel disease (four had ulcerative colitis, three had Crohn's disease), 12 had an indeterminate colitis, 12 a lymphoid nodular hyperplasia of the distal ileum as main feature. In the latter two groups, endoscopy and histology revealed an intestinal inflammation of chronic type distinct from the classical pattern found in inflammatory bowel disease. All were HLA B27 negative and fulfilled the European Spondyloarthropathy Study Group criteria for spondyloarthropathy (except five children classified as undifferentiated spondyloarthropathy). Conclusions.: In a group of children primarily investigated for suspected inflammatory bowel disease and also presenting a seronegative spondyloarthropathy we have described both intestinal and rheumatological features. The majority of them exhibited either an indeterminate colitis or a lymphoid nodular hyperplasia of the distal ileum as main feature. These patients may be a population at risk of developing a full inflammatory bowel disease phenotype.

AB - Background.: Spondyloarthropathy in adults has been shown to be associated with either clinical or subclinical intestinal inflammation, however this association has rarely been described in children. Aim.: To report paediatric patients primarily referred to a paediatric gastroenterology centre for suspected inflammatory bowel disease and found to be affected by a seronegative spondyloarthropathy. Intestinal inflammatory lesions and rheumatological features have been described in them. Subjects.: During a 18-month period, 129 children were referred because of symptoms and signs suggesting an inflammatory bowel disease; 31 of them (range age: 5-17 years) were selected because they also had signs of axial and/or peripheral arthropathy and form the basis of our study. Methods.: The investigated patients underwent ileo-colonoscopy with biopsy and rheumatological assessment that also included X-ray and magnetic resonance imaging of the sacroiliac joints. Results.: Only seven children had a classical inflammatory bowel disease (four had ulcerative colitis, three had Crohn's disease), 12 had an indeterminate colitis, 12 a lymphoid nodular hyperplasia of the distal ileum as main feature. In the latter two groups, endoscopy and histology revealed an intestinal inflammation of chronic type distinct from the classical pattern found in inflammatory bowel disease. All were HLA B27 negative and fulfilled the European Spondyloarthropathy Study Group criteria for spondyloarthropathy (except five children classified as undifferentiated spondyloarthropathy). Conclusions.: In a group of children primarily investigated for suspected inflammatory bowel disease and also presenting a seronegative spondyloarthropathy we have described both intestinal and rheumatological features. The majority of them exhibited either an indeterminate colitis or a lymphoid nodular hyperplasia of the distal ileum as main feature. These patients may be a population at risk of developing a full inflammatory bowel disease phenotype.

KW - Inflammatory bowel disease

KW - Lymphoid nodular hyperplasia (LNH)

KW - Paediatrics

KW - Spondyloarthropathy

UR - http://www.scopus.com/inward/record.url?scp=33744773553&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33744773553&partnerID=8YFLogxK

U2 - 10.1016/j.dld.2005.04.028

DO - 10.1016/j.dld.2005.04.028

M3 - Article

C2 - 16024303

AN - SCOPUS:33744773553

VL - 37

SP - 761

EP - 767

JO - Digestive and Liver Disease

JF - Digestive and Liver Disease

SN - 1590-8658

IS - 10

ER -