Chronic kidney disease is characterized by "double trouble" higher pulse pressure plus night-time systolic blood pressure and more severe cardiac damage

Massimiliano Fedecostante, Francesco Spannella, Giovanna Cola, Emma Espinosa, Paolo Dessì-Fulgheri, Riccardo Sarzani

Research output: Contribution to journalArticle

Abstract

Background: Hypertension plays a key role in chronic kidney disease (CKD), but CKD itself affects the blood pressure (BP) profile. The aim of this study was to assess the association of BP profile with CKD and the presence of cardiac organ damage. Methods: We studied 1805 patients, referred to our Hypertension Centre, in whom ABPM, blood tests, and echocardiography were clinically indicated. The glomerular filtration rate was estimated (eGFR) using the MDRD equation and CKD was defined as eGFR2. Cardiac organ damage was evaluated by echocardiography. Results: Among patients with CKD there were higher systolic blood pressure (SBP) during the night-time, greater prevalence of non-dippers (OR: 1.8) and increased pulse pressure (PP) during 24-hour period, daytime and night-time (all p2.7 index, and a higher prevalence of left ventricular hypertrophy and diastolic dysfunction (all p

Original languageEnglish
Article numbere86155
JournalPLoS One
Volume9
Issue number1
DOIs
Publication statusPublished - Jan 23 2014

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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