Chronic lead exposure alters dopaminergic mechanisms in rat pituitary

L. Lucchl, S. Govoni, M. Memo, C. Missale, P. F. Spano, M. Trabucch1

Research output: Contribution to journalArticle


The effect of chronic lead treatment on pituitary dopamine (DA) D2 receptors was studied by measuring (-)sulpiride-displaceable [3H]spiroperidol-binding and DA-inhibited adenylate cyclase. Receptor number was reduced in lead-exposed animals and bromocriptine was less able to inhibit cyclase activity in pituitary homogenates. In addition, the capacity of DA to inhibit the VIP-stimulated cAMP formation was decreased.

Original languageEnglish
Pages (from-to)255-260
Number of pages6
JournalToxicology Letters
Issue number3
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Toxicology

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