Chronic lead treatment affects dopaminergic control of prolactin secretion in rat pituitary

S. Govoni, L. Lucchi, F. Battaini, P. F. Spano, M. Trabucchi

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of lead exposure on dopaminergic mechanisms regulating prolactin (PRL) secretion was studied in rats by measuring dopamine (DA) and dihydroxyphenylacetic acid hypothalamic concentrations and DA receptor density in the hypothalamus and pituitary of lead-exposed animals. [3H]sulpiride was used as dopamine receptor ligand. A decrease of dihydroxyphenylacetic acid (DOPAC) hypothalamic concentrations and a decrease of DA receptor density in the pituitary are shown. The decreased [3H]Sulpiride binding in the pituitary is consistent with the elevated serum PRL concentrations previously described in lead-exposed rats.

Original languageEnglish
Pages (from-to)237-241
Number of pages5
JournalToxicology Letters
Volume20
Issue number3
DOIs
Publication statusPublished - 1984

Keywords

  • dihydroxyphenylacetic acid
  • dopamine
  • hypothalamus
  • Lead
  • pituitary
  • prolactin

ASJC Scopus subject areas

  • Toxicology

Fingerprint Dive into the research topics of 'Chronic lead treatment affects dopaminergic control of prolactin secretion in rat pituitary'. Together they form a unique fingerprint.

Cite this