Chronic lead treatment differentially affects dopamine synthesis in various rat brain areas

S. Govoni, M. Memo, P. F. Spano, M. Trabucchi

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of chronic dietary lead exposure on brain nigrostriatal, mesolimbic and mesocortial systems was studied. The results show no modification of the dopamine receptors measured either as dopamine sensitive adenylate cyclase or as [3H]spiroperidol binding. On the other hadn, dopamine synthesis seems to be reduced in striatum, unaffected in substantia nigra and increased in nucleus accumbens and in the frontal cortex. The increase of DA synthesis observed in some brain areas might be involved in determining the hyperactive behaviour that follows lead intoxication.

Original languageEnglish
Pages (from-to)343-349
Number of pages7
JournalToxicology
Volume12
Issue number3
DOIs
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Toxicology

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