Chronic liver disease in transfusion-dependent thalassaemia: Hepatitis B virus marker studies

S. De Virgiliis, G. Fiorelli, S. Fargion, G. Cornacchia, G. Sanna, P. Cossu, V. Murgia, A. Cao

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The systematic screening of 253 children with transfusion-dependent homozygous β-thalassaemia revealed a high incidence of hepatitis B virus markers. The highest frequencies of hepatitis B surface antigen (HBsAg) and antibody to hepatitis B core antigen (anti-HBc) were found in the group of patients with the smallest number of transfusions, while the highest frequency of antibody to hepatitis B surface antigen (anti-HBs) was detected in the patients who had had the largest number of transfusions. Follow-up of these patients showed (a) a high incidence of acute hepatitis B, which was mainly subclinical; (b) normal hepatitis B surface antigen clearance and normal antibody to hepatitis B surface development; and (c) a high frequency of increased transaminase values for over six months. In all the subjects with persistently high transaminase, histological examination revealed chronic persistent hepatitis or chronic active hepatitis. Apart from two cases of chronic active hepatitis with no B virus markers, and two cases of chronic persistent hepatitis with HBsAg and anti-HBc in the serum, all these subjects were anti-HBs positive but HBsAg and anti-HBc negative.

Original languageEnglish
Pages (from-to)949-953
Number of pages5
JournalJournal of Clinical Pathology
Issue number10
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Health Policy
  • Pathology and Forensic Medicine


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