Chronic lymphocytic leukaemia: A model for investigating potential new targets for the therapy of indolent lymphomas

Federico Caligaris-Cappio; Alessandro Cignetti; Luisa Granziero; Paolo Ghia

doi:10.1053/beha.2002.0212

Chronic lymphocytic leukaemia: A model for investigating potential new targets for the therapy of indolent lymphomas

Federico Caligaris-Cappio, Alessandro Cignetti, Luisa Granziero, Paolo Ghia

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article

Abstract

We address two key issues whose investigation may help to define new prognostic parameters and new potential targets for therapeutic intervention. First, which are the conceptual implications of the cellular origin of indolent lymphomas? Second, how may deciphering the biology of chronic lymphocytic leukaemia (CLL) lead to the development of new modalities of treatment? The latter issue is articulated in the following three key questions. (1) Which are the molecular pathways through which the microenvironment exerts its influence on the malignant clone? (2) What are the relationships between proliferation and defective apoptosis? (3)Is there any evidence of a role for antigenic stimulation?

Original language	English
Pages (from-to)	563-575
Number of pages	13
Journal	Best Practice and Research: Clinical Haematology
Volume	15
Issue number	3
DOIs	https://doi.org/10.1053/beha.2002.0212
Publication status	Published - 2002

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Keywords

Apoptosis
B lymphocytes
Chronic lymphocytic leukaemia
Indolent lymphomas
Microenvironment

ASJC Scopus subject areas

Cancer Research
Oncology

Cite this

Caligaris-Cappio, F., Cignetti, A., Granziero, L., & Ghia, P. (2002). Chronic lymphocytic leukaemia: A model for investigating potential new targets for the therapy of indolent lymphomas. Best Practice and Research: Clinical Haematology, 15(3), 563-575. https://doi.org/10.1053/beha.2002.0212

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10.1053/beha.2002.0212