Abstract
We address two key issues whose investigation may help to define new prognostic parameters and new potential targets for therapeutic intervention. First, which are the conceptual implications of the cellular origin of indolent lymphomas? Second, how may deciphering the biology of chronic lymphocytic leukaemia (CLL) lead to the development of new modalities of treatment? The latter issue is articulated in the following three key questions. (1) Which are the molecular pathways through which the microenvironment exerts its influence on the malignant clone? (2) What are the relationships between proliferation and defective apoptosis? (3)Is there any evidence of a role for antigenic stimulation?
| Original language | English |
|---|---|
| Pages (from-to) | 563-575 |
| Number of pages | 13 |
| Journal | Best Practice and Research: Clinical Haematology |
| Volume | 15 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- Apoptosis
- B lymphocytes
- Chronic lymphocytic leukaemia
- Indolent lymphomas
- Microenvironment
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Chronic lymphocytic leukaemia : A model for investigating potential new targets for the therapy of indolent lymphomas. / Caligaris-Cappio, Federico; Cignetti, Alessandro; Granziero, Luisa; Ghia, Paolo.
In: Best Practice and Research: Clinical Haematology, Vol. 15, No. 3, 2002, p. 563-575.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chronic lymphocytic leukaemia
T2 - A model for investigating potential new targets for the therapy of indolent lymphomas
AU - Caligaris-Cappio, Federico
AU - Cignetti, Alessandro
AU - Granziero, Luisa
AU - Ghia, Paolo
PY - 2002
Y1 - 2002
N2 - We address two key issues whose investigation may help to define new prognostic parameters and new potential targets for therapeutic intervention. First, which are the conceptual implications of the cellular origin of indolent lymphomas? Second, how may deciphering the biology of chronic lymphocytic leukaemia (CLL) lead to the development of new modalities of treatment? The latter issue is articulated in the following three key questions. (1) Which are the molecular pathways through which the microenvironment exerts its influence on the malignant clone? (2) What are the relationships between proliferation and defective apoptosis? (3)Is there any evidence of a role for antigenic stimulation?
AB - We address two key issues whose investigation may help to define new prognostic parameters and new potential targets for therapeutic intervention. First, which are the conceptual implications of the cellular origin of indolent lymphomas? Second, how may deciphering the biology of chronic lymphocytic leukaemia (CLL) lead to the development of new modalities of treatment? The latter issue is articulated in the following three key questions. (1) Which are the molecular pathways through which the microenvironment exerts its influence on the malignant clone? (2) What are the relationships between proliferation and defective apoptosis? (3)Is there any evidence of a role for antigenic stimulation?
KW - Apoptosis
KW - B lymphocytes
KW - Chronic lymphocytic leukaemia
KW - Indolent lymphomas
KW - Microenvironment
UR - http://www.scopus.com/inward/record.url?scp=0036455059&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036455059&partnerID=8YFLogxK
U2 - 10.1053/beha.2002.0212
DO - 10.1053/beha.2002.0212
M3 - Article
C2 - 12468406
AN - SCOPUS:0036455059
VL - 15
SP - 563
EP - 575
JO - Best Practice and Research in Clinical Haematology
JF - Best Practice and Research in Clinical Haematology
SN - 1521-6926
IS - 3
ER -