TY - JOUR
T1 - Chronic lymphocytic leukaemia and neuroendocrine cancer
AU - Russo, F.
AU - Guadagni, S.
AU - Corazzelli, G.
AU - Frigeri, F.
AU - Monda, V. M.
AU - Abate, G.
PY - 1999
Y1 - 1999
N2 - We report a unique association between neuroendocrine cancer and chronic lymphocytic leukaemia (CLL) in a 63-year-old man. Neuroendocrine cancer was resistant to various conventional treatments and following locoregional progression we treated the patient with hypoxic pelvic perfusion of cisplatin 100 mg/m2 plus mitomycin 40 mg/m2, using the stopflow method, for three cycles: a dramatic and surprising reduction of >75% in the evaluable lesions was observed. The cumulative effect of treatment produced a complete response from CLL. At cytogenetic examination the neuroendocrine cells were diploid, whereas CLL cells showed trisomy 12. Moreover, deletion of the short arm of chromosome 3 was found in both neoplastic populations. Whether the abnormality seen on chromosome 3 in the two diseases represents a critical event is not known.
AB - We report a unique association between neuroendocrine cancer and chronic lymphocytic leukaemia (CLL) in a 63-year-old man. Neuroendocrine cancer was resistant to various conventional treatments and following locoregional progression we treated the patient with hypoxic pelvic perfusion of cisplatin 100 mg/m2 plus mitomycin 40 mg/m2, using the stopflow method, for three cycles: a dramatic and surprising reduction of >75% in the evaluable lesions was observed. The cumulative effect of treatment produced a complete response from CLL. At cytogenetic examination the neuroendocrine cells were diploid, whereas CLL cells showed trisomy 12. Moreover, deletion of the short arm of chromosome 3 was found in both neoplastic populations. Whether the abnormality seen on chromosome 3 in the two diseases represents a critical event is not known.
KW - Chromosome 3 deletion
KW - Chronic lymphocytic leukaemia
KW - Neuroendocrine cancer
KW - Stopflow therapy
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U2 - 10.1046/j.1365-2141.1999.01472.x
DO - 10.1046/j.1365-2141.1999.01472.x
M3 - Article
C2 - 10554811
AN - SCOPUS:0033056686
VL - 105
SP - 989
EP - 992
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 4
ER -