Chronic lymphocytic leukaemia and neuroendocrine cancer

F. Russo, S. Guadagni, G. Corazzelli, F. Frigeri, V. M. Monda, G. Abate

Research output: Contribution to journalArticlepeer-review


We report a unique association between neuroendocrine cancer and chronic lymphocytic leukaemia (CLL) in a 63-year-old man. Neuroendocrine cancer was resistant to various conventional treatments and following locoregional progression we treated the patient with hypoxic pelvic perfusion of cisplatin 100 mg/m2 plus mitomycin 40 mg/m2, using the stopflow method, for three cycles: a dramatic and surprising reduction of >75% in the evaluable lesions was observed. The cumulative effect of treatment produced a complete response from CLL. At cytogenetic examination the neuroendocrine cells were diploid, whereas CLL cells showed trisomy 12. Moreover, deletion of the short arm of chromosome 3 was found in both neoplastic populations. Whether the abnormality seen on chromosome 3 in the two diseases represents a critical event is not known.

Original languageEnglish
Pages (from-to)989-992
Number of pages4
JournalBritish Journal of Haematology
Issue number4
Publication statusPublished - 1999


  • Chromosome 3 deletion
  • Chronic lymphocytic leukaemia
  • Neuroendocrine cancer
  • Stopflow therapy

ASJC Scopus subject areas

  • Hematology


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