Chronic lymphocytic leukaemia: New biological and therapeutical insights

Giovanni D'Arena, Michael J. Keating, Mario Carotenuto

Research output: Contribution to journalArticlepeer-review


Some of the most recent advances on biology and management of B-cell chronic lymphocytic leukaemia (BCLL) are reviewed. This paper stems from the presentations at the "Chronic lymphoproliferative disorders" session of the International Meeting "Recent Advances in Hematology 2000", helded in San Giovanni Rotondo, Italy, April 6-8, 2000. In particular, this paper focus on the biological significance of IgV mutations and CD38 expression, the quantitative expression of some antigens and their relevance in the differential diagnosis of B-cell chronic lymphoproliferative disorders (CLDs). Finally, the therapeutical shift from philosophy of palliation to the approach oriented toward obtaining a complete remission is examined in detail.

Original languageEnglish
Pages (from-to)289-296
Number of pages8
JournalTrasfusione del Sangue
Issue number6
Publication statusPublished - 2000


  • Chronic lymphocytic leukaemia
  • Diagnostic criteria
  • Therapy

ASJC Scopus subject areas

  • Hematology
  • Immunology and Allergy


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