Abstract
Objectives - A population based case-control study was conducted in a highly agricultural area in the north east of Italy to evaluate the association between farming and animal breeding and the risk of developing non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukaemia (CLL). Methods - Occupational histories and other data were collected by personal interview on 164 NHLs, 23 CLLs, diagnosed in 1988-90, and on 977 controls. This paper only reports the results of the analysis relative to the coding of job titles through the modified International Labour Office (ILO) classification. Estimates of odds ratios (ORs) for occupational variables were calculated, after adjustment for sex, age, altitude of municipality, first degree familiarity, and previous Herpes zoster infection. Results - From the analysis of the most frequent occupational categories, no occupation showed a significantly high risk. When the two job titles farmers only and farmer- breeders who are also involved in animal breeding are classified within the extremely varied occupation of agriculture or animal-breeding or fishing, a high risk for NHLs and CLLs in seen in the farmer-breeders (OR 1.79, 95% CI 1.22-2.63). Analyses according to histological type show that the risks are concentrated in CLLs and in low grade NHLs. No effect or trend by period at work or duration of employment in farming and animal breeding was found. Conclusion - Subjects working in agriculture associated with animal breeding are at high risk of NHL/CLLs, particularly CLLs and low grade NHLs. This finding could be related to the use of chemicals in agriculture or to exposure to animal transmitted diseases or specific chemicals used in animal breeding.
| Original language | English |
|---|---|
| Pages (from-to) | 374-379 |
| Number of pages | 6 |
| Journal | Occupational and Environmental Medicine |
| Volume | 52 |
| Issue number | 6 |
| Publication status | Published - 1995 |
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Keywords
- agriculture
- animal breeding
- chronic lymphocytic leukaemia
- non-Hodgkin's lymphoma
ASJC Scopus subject areas
- Environmental Science(all)
- Public Health, Environmental and Occupational Health
Cite this
Chronic lymphocytic leukaemias and non-Hodgkin's lymphomas by histological type in farming-animal breeding workers : A population case-control study based on job titles. / Amadori, D.; Nanni, O.; Falcini, F.; Saragoni, A.; Tison, V.; Callea, A.; Scarpi, E.; Ricci, M.; Riva, N.; Buiatti, E.
In: Occupational and Environmental Medicine, Vol. 52, No. 6, 1995, p. 374-379.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chronic lymphocytic leukaemias and non-Hodgkin's lymphomas by histological type in farming-animal breeding workers
T2 - A population case-control study based on job titles
AU - Amadori, D.
AU - Nanni, O.
AU - Falcini, F.
AU - Saragoni, A.
AU - Tison, V.
AU - Callea, A.
AU - Scarpi, E.
AU - Ricci, M.
AU - Riva, N.
AU - Buiatti, E.
PY - 1995
Y1 - 1995
N2 - Objectives - A population based case-control study was conducted in a highly agricultural area in the north east of Italy to evaluate the association between farming and animal breeding and the risk of developing non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukaemia (CLL). Methods - Occupational histories and other data were collected by personal interview on 164 NHLs, 23 CLLs, diagnosed in 1988-90, and on 977 controls. This paper only reports the results of the analysis relative to the coding of job titles through the modified International Labour Office (ILO) classification. Estimates of odds ratios (ORs) for occupational variables were calculated, after adjustment for sex, age, altitude of municipality, first degree familiarity, and previous Herpes zoster infection. Results - From the analysis of the most frequent occupational categories, no occupation showed a significantly high risk. When the two job titles farmers only and farmer- breeders who are also involved in animal breeding are classified within the extremely varied occupation of agriculture or animal-breeding or fishing, a high risk for NHLs and CLLs in seen in the farmer-breeders (OR 1.79, 95% CI 1.22-2.63). Analyses according to histological type show that the risks are concentrated in CLLs and in low grade NHLs. No effect or trend by period at work or duration of employment in farming and animal breeding was found. Conclusion - Subjects working in agriculture associated with animal breeding are at high risk of NHL/CLLs, particularly CLLs and low grade NHLs. This finding could be related to the use of chemicals in agriculture or to exposure to animal transmitted diseases or specific chemicals used in animal breeding.
AB - Objectives - A population based case-control study was conducted in a highly agricultural area in the north east of Italy to evaluate the association between farming and animal breeding and the risk of developing non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukaemia (CLL). Methods - Occupational histories and other data were collected by personal interview on 164 NHLs, 23 CLLs, diagnosed in 1988-90, and on 977 controls. This paper only reports the results of the analysis relative to the coding of job titles through the modified International Labour Office (ILO) classification. Estimates of odds ratios (ORs) for occupational variables were calculated, after adjustment for sex, age, altitude of municipality, first degree familiarity, and previous Herpes zoster infection. Results - From the analysis of the most frequent occupational categories, no occupation showed a significantly high risk. When the two job titles farmers only and farmer- breeders who are also involved in animal breeding are classified within the extremely varied occupation of agriculture or animal-breeding or fishing, a high risk for NHLs and CLLs in seen in the farmer-breeders (OR 1.79, 95% CI 1.22-2.63). Analyses according to histological type show that the risks are concentrated in CLLs and in low grade NHLs. No effect or trend by period at work or duration of employment in farming and animal breeding was found. Conclusion - Subjects working in agriculture associated with animal breeding are at high risk of NHL/CLLs, particularly CLLs and low grade NHLs. This finding could be related to the use of chemicals in agriculture or to exposure to animal transmitted diseases or specific chemicals used in animal breeding.
KW - agriculture
KW - animal breeding
KW - chronic lymphocytic leukaemia
KW - non-Hodgkin's lymphoma
UR - http://www.scopus.com/inward/record.url?scp=0029068154&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029068154&partnerID=8YFLogxK
M3 - Article
VL - 52
SP - 374
EP - 379
JO - Occupational and Environmental Medicine
JF - Occupational and Environmental Medicine
SN - 1351-0711
IS - 6
ER -