TY - JOUR
T1 - Chronic lymphocytic leukemia
T2 - The pathologist's view of lymph node microenvironment
AU - Ponzoni, Maurilio
AU - Doglioni, Claudio
AU - Caligaris-Cappio, Federico
PY - 2011/5
Y1 - 2011/5
N2 - Chronic lymphocytic leukemia (CLL), an indolent B-cell malignancy frequently diagnosed in the elderly, is characterized by the relentless accumulation of CD5
+ monoclonal B cells that proliferate in the appropriate tissue microenvironments. Despite many advances achieved by molecular and functional studies, our knowledge of the reciprocal relationship between the CLL cell and its microenvironment at the tissue level is still largely incomplete. In this review we present the relevant current information on the tissue microenvironmental features of CLL, focusing on the events that appear to occur in the lymph node. Special attention is devoted to analyzing the properties of both neoplastic and nonneoplastic bystander cells within proliferation centers, the mysterious structures that likely represent the actual proliferative compartment.
AB - Chronic lymphocytic leukemia (CLL), an indolent B-cell malignancy frequently diagnosed in the elderly, is characterized by the relentless accumulation of CD5
+ monoclonal B cells that proliferate in the appropriate tissue microenvironments. Despite many advances achieved by molecular and functional studies, our knowledge of the reciprocal relationship between the CLL cell and its microenvironment at the tissue level is still largely incomplete. In this review we present the relevant current information on the tissue microenvironmental features of CLL, focusing on the events that appear to occur in the lymph node. Special attention is devoted to analyzing the properties of both neoplastic and nonneoplastic bystander cells within proliferation centers, the mysterious structures that likely represent the actual proliferative compartment.
KW - Chronic lymphocytic leukemia
KW - Lymphocyte
KW - Microenvironment
KW - Proliferation centers
KW - Stroma
KW - Vessels
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U2 - 10.1053/j.semdp.2011.02.014
DO - 10.1053/j.semdp.2011.02.014
M3 - Article
C2 - 21842701
AN - SCOPUS:79958008875
VL - 28
SP - 161
EP - 166
JO - Seminars in Diagnostic Pathology
JF - Seminars in Diagnostic Pathology
SN - 0740-2570
IS - 2
ER -