Chronic lymphoproliferative disorders: An integrated point of view for the differential diagnosis

Giovanni D'Arena, Michael J. Keating, Mario Carotenuto

Research output: Contribution to journalArticle

Abstract

Morphology is regarded as the principle basis for the identification of lymphoid neoplasms. Sometimes, however, it fails to discriminate among several chronic lymphoproliferative disorders (CLDs). Improved immunophenotyping has resulted in a better characterization of a number of variants of these diseases, some of which may benefit from different therapeutic approaches. In particular, the proposal of scoring systems using a panel of monoclonal antibodies (MoAbs) has represented a critical step in this field. In fact, to date, some MoAbs (CD5, CD23, FMC7, CD22, CD79b, and surface immunoglobulin density) are able to distinguish among several entities, thus allowing for a correct diagnosis in the majority of cases. However, there is still a small percentage of patients where the combined diagnostic approach (morphology and immunophenotyping) should be further refined by other techniques, such as cytogenetic and molecular characterization. Here numerous questions are raised indicating the need to more accurately differentiate the disease entities under discussion and better understand some of their clinical manifestations.

Original languageEnglish
Pages (from-to)225-237
Number of pages13
JournalLeukemia and Lymphoma
Volume36
Issue number3-4
Publication statusPublished - 2000

Fingerprint

Immunophenotyping
Lymphoproliferative Disorders
Differential Diagnosis
Monoclonal Antibodies
B-Cell Antigen Receptors
Cytogenetics
Neoplasms
Therapeutics

Keywords

  • Chronic lymphoproliferative disorders
  • Diagnosis
  • Flow cytometry
  • Immunology
  • Morphology

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Chronic lymphoproliferative disorders : An integrated point of view for the differential diagnosis. / D'Arena, Giovanni; Keating, Michael J.; Carotenuto, Mario.

In: Leukemia and Lymphoma, Vol. 36, No. 3-4, 2000, p. 225-237.

Research output: Contribution to journalArticle

D'Arena, Giovanni ; Keating, Michael J. ; Carotenuto, Mario. / Chronic lymphoproliferative disorders : An integrated point of view for the differential diagnosis. In: Leukemia and Lymphoma. 2000 ; Vol. 36, No. 3-4. pp. 225-237.
@article{1436da8a94714213aa558a3b6c910c3d,
title = "Chronic lymphoproliferative disorders: An integrated point of view for the differential diagnosis",
abstract = "Morphology is regarded as the principle basis for the identification of lymphoid neoplasms. Sometimes, however, it fails to discriminate among several chronic lymphoproliferative disorders (CLDs). Improved immunophenotyping has resulted in a better characterization of a number of variants of these diseases, some of which may benefit from different therapeutic approaches. In particular, the proposal of scoring systems using a panel of monoclonal antibodies (MoAbs) has represented a critical step in this field. In fact, to date, some MoAbs (CD5, CD23, FMC7, CD22, CD79b, and surface immunoglobulin density) are able to distinguish among several entities, thus allowing for a correct diagnosis in the majority of cases. However, there is still a small percentage of patients where the combined diagnostic approach (morphology and immunophenotyping) should be further refined by other techniques, such as cytogenetic and molecular characterization. Here numerous questions are raised indicating the need to more accurately differentiate the disease entities under discussion and better understand some of their clinical manifestations.",
keywords = "Chronic lymphoproliferative disorders, Diagnosis, Flow cytometry, Immunology, Morphology",
author = "Giovanni D'Arena and Keating, {Michael J.} and Mario Carotenuto",
year = "2000",
language = "English",
volume = "36",
pages = "225--237",
journal = "Leukemia and Lymphoma",
issn = "1042-8194",
publisher = "Taylor and Francis Ltd.",
number = "3-4",

}

TY - JOUR

T1 - Chronic lymphoproliferative disorders

T2 - An integrated point of view for the differential diagnosis

AU - D'Arena, Giovanni

AU - Keating, Michael J.

AU - Carotenuto, Mario

PY - 2000

Y1 - 2000

N2 - Morphology is regarded as the principle basis for the identification of lymphoid neoplasms. Sometimes, however, it fails to discriminate among several chronic lymphoproliferative disorders (CLDs). Improved immunophenotyping has resulted in a better characterization of a number of variants of these diseases, some of which may benefit from different therapeutic approaches. In particular, the proposal of scoring systems using a panel of monoclonal antibodies (MoAbs) has represented a critical step in this field. In fact, to date, some MoAbs (CD5, CD23, FMC7, CD22, CD79b, and surface immunoglobulin density) are able to distinguish among several entities, thus allowing for a correct diagnosis in the majority of cases. However, there is still a small percentage of patients where the combined diagnostic approach (morphology and immunophenotyping) should be further refined by other techniques, such as cytogenetic and molecular characterization. Here numerous questions are raised indicating the need to more accurately differentiate the disease entities under discussion and better understand some of their clinical manifestations.

AB - Morphology is regarded as the principle basis for the identification of lymphoid neoplasms. Sometimes, however, it fails to discriminate among several chronic lymphoproliferative disorders (CLDs). Improved immunophenotyping has resulted in a better characterization of a number of variants of these diseases, some of which may benefit from different therapeutic approaches. In particular, the proposal of scoring systems using a panel of monoclonal antibodies (MoAbs) has represented a critical step in this field. In fact, to date, some MoAbs (CD5, CD23, FMC7, CD22, CD79b, and surface immunoglobulin density) are able to distinguish among several entities, thus allowing for a correct diagnosis in the majority of cases. However, there is still a small percentage of patients where the combined diagnostic approach (morphology and immunophenotyping) should be further refined by other techniques, such as cytogenetic and molecular characterization. Here numerous questions are raised indicating the need to more accurately differentiate the disease entities under discussion and better understand some of their clinical manifestations.

KW - Chronic lymphoproliferative disorders

KW - Diagnosis

KW - Flow cytometry

KW - Immunology

KW - Morphology

UR - http://www.scopus.com/inward/record.url?scp=0033983131&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033983131&partnerID=8YFLogxK

M3 - Article

C2 - 10674895

AN - SCOPUS:0033983131

VL - 36

SP - 225

EP - 237

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

SN - 1042-8194

IS - 3-4

ER -