Chronic myelogenous leukemia and exposure to ionizing radiation - a retrospective study of 443 patients

A. Corso, M. Lazzarino, E. Morra, S. Merante, C. Astori, P. Bernasconi, M. Boni, C. Bernasconi

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Exposure to ionizing radiations (Rx) has been implicated as a causative factor of chronic myelogenous leukemia (CML). We performed a retrospective study of 443 consecutive CML patients, looking for a history of significant exposure to Rx, and evaluated the clinical and hematological characteristics in order to find any difference between radiation-related CML patients and those with de novo CML. We identified 406 patients without known exposure to mutagens (group I) and 37 patients with prior significant exposure to Rx (group II). In comparison to patients of group I, those of group II showed particular clinical and hematological features: significantly lower incidence of bulky splenomegaly (p100×109/l;p

Original languageEnglish
Pages (from-to)79-82
Number of pages4
JournalAnnals of Hematology
Issue number2
Publication statusPublished - Feb 1995



  • Chronic myeloid leukemia Radiotherapy
  • X-ray treatment

ASJC Scopus subject areas

  • Hematology

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