TY - JOUR
T1 - Chronic myeloid leukemia stem cells
AU - Houshmand, Mohammad
AU - Simonetti, Giorgia
AU - Circosta, Paola
AU - Gaidano, Valentina
AU - Cignetti, Alessandro
AU - Martinelli, Giovanni
AU - Saglio, Giuseppe
AU - Gale, Robert Peter
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Chronic myeloid leukemia (CML) is caused by BCRABL1 in a cell with the biological potential, intrinsic or acquired, to cause leukemia. This cell is commonly termed the CML leukemia stem cell (LSC). In humans a CML LSC is operationally-defined by ≥1 in vitro or in vivo assays of human leukemia cells transferred to immune-deficient mice. Results of these assays are sometimes discordant. There is also the unproved assumption that biological features of a CML LSC are stable. These considerations make accurate and precise identification of a CML LSC difficult or impossible. In this review, we consider biological features of CML LSCs defined by these assays. We also consider whether CML LSCs are susceptible to targeting by tyrosine kinase inhibitors (TKIs) and other drugs, and whether elimination of CML LSCs is needed to achieve therapy-free remission or cure CML.
AB - Chronic myeloid leukemia (CML) is caused by BCRABL1 in a cell with the biological potential, intrinsic or acquired, to cause leukemia. This cell is commonly termed the CML leukemia stem cell (LSC). In humans a CML LSC is operationally-defined by ≥1 in vitro or in vivo assays of human leukemia cells transferred to immune-deficient mice. Results of these assays are sometimes discordant. There is also the unproved assumption that biological features of a CML LSC are stable. These considerations make accurate and precise identification of a CML LSC difficult or impossible. In this review, we consider biological features of CML LSCs defined by these assays. We also consider whether CML LSCs are susceptible to targeting by tyrosine kinase inhibitors (TKIs) and other drugs, and whether elimination of CML LSCs is needed to achieve therapy-free remission or cure CML.
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U2 - 10.1038/s41375-019-0490-0
DO - 10.1038/s41375-019-0490-0
M3 - Review article
C2 - 31127148
AN - SCOPUS:85066904764
VL - 33
SP - 1543
EP - 1556
JO - Leukemia
JF - Leukemia
SN - 0887-6924
IS - 7
ER -