It is suggested that Malignant Hyperthermia Myopathy in man may be the same disease as the porcine stress syndrome with the pale, soft, exudative (PSE) condition. To prevent the PSE condition in stress-susceptible pigs back-crosses (F1-F2) were carried out from stress susceptible (Landrace) and stress-resistant animals (Large-White). The F2 animals showed weakness of the posterior muscles of the thigh. On macroscopical examination, the F2 muscle appeared normal in colour and texture; histochemically, central accumulation of PAS-positive material was shown in type II muscle fibres of the longissimus dorsi. In the same areas in the fibres it was possible to demonstrate accumulation of phosphorylase, alpha-glucan-phosphorylase and glycogen synthetase. In this new myopathy, hyperthermia was never observed.
ASJC Scopus subject areas
- Animal Science and Zoology