Chronic neuroleptic treatment: D2 dopamine receptor supersensitivity and striatal glutamatergic transmission

P. Calabresi, M. De Murtas, N. B. Mercuri, G. Bernardi

Research output: Contribution to journalArticle

Abstract

We studied the in vitro electrical activity of rat neostriatal neurons following chronic neuroleptic treatment. In haloperidol-treated rats, unlike naive animals, activation of neostriatal D2 dopamine receptors induced a potent presynaptic inhibition of glutamate-mediated excitatory synaptic potentials. Haloperidol treatment did not affect the intrinsic membrane properties of the neostriatal neurons. Pre- and postsynaptic physiological responses to direct and indirect gamma-aminobutyric acid (GABA)-ergic and cholinergic agonists were not affected by chronic haloperidol treatment. These findings suggest that movement disorders induced by chronic neuroleptic treatment may result, at least in part, from a hypersensitivity of presynaptic D2 dopamine receptors regulating the release of glutamate.

Original languageEnglish
Pages (from-to)366-373
Number of pages8
JournalAnnals of Neurology
Volume31
Issue number4
DOIs
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Neuroscience(all)

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