Chronic nonbacterial osteomyelitis may be associated with renal disease and bisphosphonates are a good option for the majority of patients

Serena Pastore, Giovanna Ferrara, Lorenzo Monasta, Antonella Meini, Marco Cattalini, Silvana Martino, Maria Alessio, Francesco La Torre, Barbara Teruzzi, Valeria Gerloni, Luciana Breda, Andrea Taddio, Loredana Lepore

Research output: Contribution to journalArticle

Abstract

Aim The aim of this Italian study was to describe the clinical features, treatment options and outcomes of a cohort of patients with chronic nonbacterial osteomyelitis (CNO). Methods This was a retrospective cohort study. Laboratory data, diagnostic imaging, histological features and clinical course are reported. Results We enrolled 47 patients diagnosed with CNO. Bone pain was the leading symptom, and multifocal disease was present in 87% of the patients. The majority of the bone lesions were located in the appendicular skeleton (58%). Extraosseous manifestations were present in 34% of the patients, and renal involvement was detected in four patients. Inflammatory indices were increased in 80%, and bone x-rays were negative in 15% of the patients. Nonsteroidal anti-inflammatory drugs (NSAIDs) were the first therapy for all patients, achieving clinical remission in 27%. A good response to NSAIDs was significantly associated with a better prognosis. Bisphosphonates were used in 26 patients, with remission in 73%. Only six patients (13%), all with spine involvement, developed sequelae. Conclusion We found a possible association between CNO and renal disease. Bisphosphonates were more likely to lead to clinical remission when NSAIDs and corticosteroids had failed. Vertebral localisation was the only risk factor for potential sequelae.

Original languageEnglish
Pages (from-to)e328-e333
JournalActa Paediatrica, International Journal of Paediatrics
Volume105
Issue number7
DOIs
Publication statusPublished - Jul 1 2016

Fingerprint

Diphosphonates
Osteomyelitis
Kidney
Anti-Inflammatory Agents
Bone and Bones
Pharmaceutical Preparations
Diagnostic Imaging
Skeleton
Adrenal Cortex Hormones
Spine
Cohort Studies
Retrospective Studies
X-Rays
Pain

Keywords

  • Bisphosphonates
  • Bone pain
  • Children
  • Chronic nonbacterial osteomyelitis
  • Chronic recurrent multifocal osteomyelitis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Chronic nonbacterial osteomyelitis may be associated with renal disease and bisphosphonates are a good option for the majority of patients. / Pastore, Serena; Ferrara, Giovanna; Monasta, Lorenzo; Meini, Antonella; Cattalini, Marco; Martino, Silvana; Alessio, Maria; La Torre, Francesco; Teruzzi, Barbara; Gerloni, Valeria; Breda, Luciana; Taddio, Andrea; Lepore, Loredana.

In: Acta Paediatrica, International Journal of Paediatrics, Vol. 105, No. 7, 01.07.2016, p. e328-e333.

Research output: Contribution to journalArticle

Pastore, Serena ; Ferrara, Giovanna ; Monasta, Lorenzo ; Meini, Antonella ; Cattalini, Marco ; Martino, Silvana ; Alessio, Maria ; La Torre, Francesco ; Teruzzi, Barbara ; Gerloni, Valeria ; Breda, Luciana ; Taddio, Andrea ; Lepore, Loredana. / Chronic nonbacterial osteomyelitis may be associated with renal disease and bisphosphonates are a good option for the majority of patients. In: Acta Paediatrica, International Journal of Paediatrics. 2016 ; Vol. 105, No. 7. pp. e328-e333.
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abstract = "Aim The aim of this Italian study was to describe the clinical features, treatment options and outcomes of a cohort of patients with chronic nonbacterial osteomyelitis (CNO). Methods This was a retrospective cohort study. Laboratory data, diagnostic imaging, histological features and clinical course are reported. Results We enrolled 47 patients diagnosed with CNO. Bone pain was the leading symptom, and multifocal disease was present in 87{\%} of the patients. The majority of the bone lesions were located in the appendicular skeleton (58{\%}). Extraosseous manifestations were present in 34{\%} of the patients, and renal involvement was detected in four patients. Inflammatory indices were increased in 80{\%}, and bone x-rays were negative in 15{\%} of the patients. Nonsteroidal anti-inflammatory drugs (NSAIDs) were the first therapy for all patients, achieving clinical remission in 27{\%}. A good response to NSAIDs was significantly associated with a better prognosis. Bisphosphonates were used in 26 patients, with remission in 73{\%}. Only six patients (13{\%}), all with spine involvement, developed sequelae. Conclusion We found a possible association between CNO and renal disease. Bisphosphonates were more likely to lead to clinical remission when NSAIDs and corticosteroids had failed. Vertebral localisation was the only risk factor for potential sequelae.",
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AU - Ferrara, Giovanna

AU - Monasta, Lorenzo

AU - Meini, Antonella

AU - Cattalini, Marco

AU - Martino, Silvana

AU - Alessio, Maria

AU - La Torre, Francesco

AU - Teruzzi, Barbara

AU - Gerloni, Valeria

AU - Breda, Luciana

AU - Taddio, Andrea

AU - Lepore, Loredana

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AB - Aim The aim of this Italian study was to describe the clinical features, treatment options and outcomes of a cohort of patients with chronic nonbacterial osteomyelitis (CNO). Methods This was a retrospective cohort study. Laboratory data, diagnostic imaging, histological features and clinical course are reported. Results We enrolled 47 patients diagnosed with CNO. Bone pain was the leading symptom, and multifocal disease was present in 87% of the patients. The majority of the bone lesions were located in the appendicular skeleton (58%). Extraosseous manifestations were present in 34% of the patients, and renal involvement was detected in four patients. Inflammatory indices were increased in 80%, and bone x-rays were negative in 15% of the patients. Nonsteroidal anti-inflammatory drugs (NSAIDs) were the first therapy for all patients, achieving clinical remission in 27%. A good response to NSAIDs was significantly associated with a better prognosis. Bisphosphonates were used in 26 patients, with remission in 73%. Only six patients (13%), all with spine involvement, developed sequelae. Conclusion We found a possible association between CNO and renal disease. Bisphosphonates were more likely to lead to clinical remission when NSAIDs and corticosteroids had failed. Vertebral localisation was the only risk factor for potential sequelae.

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