Chronic paroxysmal hemicrania: a chronobiological study (case report).

G. Micieli, A. Cavallini, F. Facchinetti, G. Sances, G. Nappi

Research output: Contribution to journalArticlepeer-review


In this study the 24-h pattern of blood pressure (BP), heart rate (HR), plasma catecholamine (CA), beta-endorphin (beta-EP), beta-lipotropin (beta-LPH) and RIII threshold was investigated in a patient suffering from chronic paroxysmal hemicrania (CPH). The investigation was carried out before and during indomethacin therapy in order to assess the presence or otherwise of a disordered biorhythmic organization resembling that documented in cluster headache (CH). A severe alteration in the majority of the rhythms explored was found not only during the drug-free phase, but also in the indomethacin phase of the investigation. These data are similar to those obtained in CH studies and point to the possibility of a common pathophysiological mechanism.

Original languageEnglish
Pages (from-to)281-286
Number of pages6
Issue number4
Publication statusPublished - Dec 1989

ASJC Scopus subject areas

  • Clinical Neurology


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