Chronic periaortitis and HLA-DRB1*03: Another clue to an autoimmune origin

Davide Martorana, Augusto Vaglio, Paolo Greco, Adele Zanetti, Gabriella Moroni, Carlo Salvarani, Mario Savi, Carlo Buzio, Tauro M. Neri

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Objective. Patients with chronic periaortitis (CP) often show clinical and laboratory findings of a systemic autoimmune disorder. The aim of the present study was to investigate the role of the HLA system in CP. Methods. Low-resolution genotyping for HLA-A, HLA-B, and HLA-DRB1 loci and genotyping of TNFA(-238)A/G and TNFA(-308)A/G single nucleotide polymorphisms were performed in 35 consecutive patients with CP and 350 healthy controls. Results. The HLA-DRB1*03 allele frequency was strikingly higher in patients with CP than in controls (24.28% versus 9.14%; χ 2 = 15.50, P = 0.000084, corrected P [P corr] = 0.0012, odds ratio [OR] 3.187, 95% confidence interval [95% CI] 1.74-5.83); the HLA-B*08 allele frequency was also higher in patients than in controls (17.14% versus 6.28%; χ 2 =11.12, P = 0.0008, P corr = 0.0269, OR 3.085, 95% CI 1.54-6.16). The A*01 allele frequency was significantly different (P = 0.0463), but the statistical significance was lost after correction for multiple testing (P corr = 0.5088). TNFA(-238)A allele and TNFA(-308)A allele frequencies were not significantly different (P = 0.512 and P = 0.445, respectively). Comparison of the main clinical and laboratory findings suggestive of a systemic autoimmune disease (e.g., acute-phase reactants, constitutional symptoms, other autoimmune diseases associated with CP) between the HLA-DRB1*03-positive and the HLA-DRB1*03-negative patients showed that the former group had significantly higher levels of C-reactive protein (P = 0.045) at disease onset, although this difference was not statistically significant after correction for multiple tests (P corr = 0.369). Conclusion. The HLA system plays a role in susceptibility to CP. The strong association between CP and HLA-DRB1*03, an allele linked to a wide range of autoimmune conditions, further supports the view that CP may represent a clinical manifestation of an autoimmune disease.

Original languageEnglish
Pages (from-to)126-130
Number of pages5
JournalArthritis Care and Research
Volume55
Issue number1
DOIs
Publication statusPublished - Feb 15 2006

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Retroperitoneal Fibrosis
HLA-DRB1 Chains
Gene Frequency
Autoimmune Diseases
HLA-B Antigens
Alleles
Odds Ratio
Confidence Intervals
HLA-A Antigens
Acute-Phase Proteins
C-Reactive Protein
Single Nucleotide Polymorphism

Keywords

  • Autoimmune disease
  • Chronic periaortitis
  • HLA-DRB1*03
  • Retroperitoneal fibrosis

ASJC Scopus subject areas

  • Rheumatology

Cite this

Chronic periaortitis and HLA-DRB1*03 : Another clue to an autoimmune origin. / Martorana, Davide; Vaglio, Augusto; Greco, Paolo; Zanetti, Adele; Moroni, Gabriella; Salvarani, Carlo; Savi, Mario; Buzio, Carlo; Neri, Tauro M.

In: Arthritis Care and Research, Vol. 55, No. 1, 15.02.2006, p. 126-130.

Research output: Contribution to journalArticle

Martorana, D, Vaglio, A, Greco, P, Zanetti, A, Moroni, G, Salvarani, C, Savi, M, Buzio, C & Neri, TM 2006, 'Chronic periaortitis and HLA-DRB1*03: Another clue to an autoimmune origin', Arthritis Care and Research, vol. 55, no. 1, pp. 126-130. https://doi.org/10.1002/art.21698
Martorana, Davide ; Vaglio, Augusto ; Greco, Paolo ; Zanetti, Adele ; Moroni, Gabriella ; Salvarani, Carlo ; Savi, Mario ; Buzio, Carlo ; Neri, Tauro M. / Chronic periaortitis and HLA-DRB1*03 : Another clue to an autoimmune origin. In: Arthritis Care and Research. 2006 ; Vol. 55, No. 1. pp. 126-130.
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AU - Zanetti, Adele

AU - Moroni, Gabriella

AU - Salvarani, Carlo

AU - Savi, Mario

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N2 - Objective. Patients with chronic periaortitis (CP) often show clinical and laboratory findings of a systemic autoimmune disorder. The aim of the present study was to investigate the role of the HLA system in CP. Methods. Low-resolution genotyping for HLA-A, HLA-B, and HLA-DRB1 loci and genotyping of TNFA(-238)A/G and TNFA(-308)A/G single nucleotide polymorphisms were performed in 35 consecutive patients with CP and 350 healthy controls. Results. The HLA-DRB1*03 allele frequency was strikingly higher in patients with CP than in controls (24.28% versus 9.14%; χ 2 = 15.50, P = 0.000084, corrected P [P corr] = 0.0012, odds ratio [OR] 3.187, 95% confidence interval [95% CI] 1.74-5.83); the HLA-B*08 allele frequency was also higher in patients than in controls (17.14% versus 6.28%; χ 2 =11.12, P = 0.0008, P corr = 0.0269, OR 3.085, 95% CI 1.54-6.16). The A*01 allele frequency was significantly different (P = 0.0463), but the statistical significance was lost after correction for multiple testing (P corr = 0.5088). TNFA(-238)A allele and TNFA(-308)A allele frequencies were not significantly different (P = 0.512 and P = 0.445, respectively). Comparison of the main clinical and laboratory findings suggestive of a systemic autoimmune disease (e.g., acute-phase reactants, constitutional symptoms, other autoimmune diseases associated with CP) between the HLA-DRB1*03-positive and the HLA-DRB1*03-negative patients showed that the former group had significantly higher levels of C-reactive protein (P = 0.045) at disease onset, although this difference was not statistically significant after correction for multiple tests (P corr = 0.369). Conclusion. The HLA system plays a role in susceptibility to CP. The strong association between CP and HLA-DRB1*03, an allele linked to a wide range of autoimmune conditions, further supports the view that CP may represent a clinical manifestation of an autoimmune disease.

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