L'osteomielite cronica multifocale ricorrente: Se la conosci la riconosci

Translated title of the contribution: Chronic recurrent multifocal osteomyelitis: If you know it you recognize it

Giovanna Ferrara, Chiara Sandrin, Serena Pastore, Giulia Gortani, Andrea Taddio, Alessandro Ventura

Research output: Contribution to journalArticle

Abstract

Chronic recurrent multifocal osteomyelitis (CRMO) is a rare inflammatory disorder that primarily affects children. Pathogenesis is still unknown. It is characterized by insidious onset of pain, local bone expansion and radiological findings suggestive of osteomyelitis at multiple sites. CRMO predominantly affects metaphyses of long bones but clavicle and mandible are suggestive of diagnosis. CRMO is a diagnosis of exclusion. Differential diagnosis includes infectious, malignancies, benign bone tumors, metabolic disorders and other autoinflammatory disorders, so a biopsy of the bone lesion is required. NSAIDs are the first-choice treatment. Alternative therapies have been used, including corticosteroids, methotrexate, bisphosphonates and TNF alpha-inhibitors. The paper reports one case of involvement of mandible, reviews the literature and describes the experience with CRMO over the past ten years.

Original languageItalian
Pages (from-to)571-575
Number of pages5
JournalMedico e Bambino
Volume33
Issue number7
Publication statusPublished - Sep 1 2014

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Bone and Bones
Mandible
Clavicle
Non-Steroidal Anti-Inflammatory Agents
Osteomyelitis
Complementary Therapies
Neoplasms
Adrenal Cortex Hormones
Differential Diagnosis
Tumor Necrosis Factor-alpha
Biopsy
Pain
Chronic recurrent multifocal osteomyelitis
Therapeutics
methotrexate bisphosphonate

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

L'osteomielite cronica multifocale ricorrente : Se la conosci la riconosci. / Ferrara, Giovanna; Sandrin, Chiara; Pastore, Serena; Gortani, Giulia; Taddio, Andrea; Ventura, Alessandro.

In: Medico e Bambino, Vol. 33, No. 7, 01.09.2014, p. 571-575.

Research output: Contribution to journalArticle

Ferrara, Giovanna ; Sandrin, Chiara ; Pastore, Serena ; Gortani, Giulia ; Taddio, Andrea ; Ventura, Alessandro. / L'osteomielite cronica multifocale ricorrente : Se la conosci la riconosci. In: Medico e Bambino. 2014 ; Vol. 33, No. 7. pp. 571-575.
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