TY - JOUR
T1 - Chronic schizophrenia as a brain misconnection syndrome
T2 - A white matter voxel-based morphometry study
AU - Spalletta, Gianfranco
AU - Tomaiuolo, Francesco
AU - Marino, Vittorio
AU - Bonaviri, Giuseppina
AU - Trequattrini, Alberto
AU - Caltagirone, Carlo
PY - 2003/11/1
Y1 - 2003/11/1
N2 - It has been hypothesized that schizophrenia could be due to a defect of neural circuitry, that is a misconnection between different cerebral areas, particularly those involved in language processing and production. A group of 28 patients with chronic schizophrenia were investigated in order to detect differences in locations of white matter voxel signal intensity in comparison with a control group of 28 normal subjects matched for age, gender and educational level. Voxel-based morphometry was used to assess the white matter of the brain. Significant voxel signal hypointensity was identified in schizophrenic patients bilaterally (mainly in the left hemisphere) in the post-central gyrus and superior temporal gyrus and unilaterally (in the left hemisphere) in the inferior frontal gyrus - pars triangularis and pars pretriangularis, the medial orbital gyrus, the lateral orbital gyrus and the rectus gyrus. Thus, the white matters of these cerebral areas were structurally modified particularly in the left hemisphere and in those structures that control language and hearing processes.
AB - It has been hypothesized that schizophrenia could be due to a defect of neural circuitry, that is a misconnection between different cerebral areas, particularly those involved in language processing and production. A group of 28 patients with chronic schizophrenia were investigated in order to detect differences in locations of white matter voxel signal intensity in comparison with a control group of 28 normal subjects matched for age, gender and educational level. Voxel-based morphometry was used to assess the white matter of the brain. Significant voxel signal hypointensity was identified in schizophrenic patients bilaterally (mainly in the left hemisphere) in the post-central gyrus and superior temporal gyrus and unilaterally (in the left hemisphere) in the inferior frontal gyrus - pars triangularis and pars pretriangularis, the medial orbital gyrus, the lateral orbital gyrus and the rectus gyrus. Thus, the white matters of these cerebral areas were structurally modified particularly in the left hemisphere and in those structures that control language and hearing processes.
KW - Language
KW - Misconnection
KW - Morphometry
KW - MRI
KW - Schizophrenia
KW - White matter
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U2 - 10.1016/S0920-9964(03)00010-0
DO - 10.1016/S0920-9964(03)00010-0
M3 - Article
C2 - 14511797
AN - SCOPUS:0141679214
VL - 64
SP - 15
EP - 23
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 1
ER -